Closure of the left atrial appendage to prevent strokes in atrial fibrillation patients
Left Atrial Appendage Closure Registry of Henri Mondor Hospital
This study is testing whether a procedure to close a small part of the heart can help people with atrial fibrillation reduce their risk of strokes instead of relying on long-term blood thinners.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Créteil) |
| Trial ID | NCT05565209 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with atrial fibrillation who are at high risk of stroke due to thrombus formation in the left atrial appendage. It evaluates the long-term efficacy of a percutaneous left atrial appendage closure procedure, which involves implanting a device to prevent blood clots from causing strokes. The study will follow 150 patients over a period of five years to assess the outcomes of this intervention. The aim is to provide insights into the effectiveness of this procedure as an alternative to long-term anticoagulation therapy.
Who should consider this trial
Good fit: Ideal candidates include patients with atrial fibrillation who are indicated for left atrial appendage closure and are unable to take anticoagulants.
Not a fit: Patients who are minors, refuse participation, or are not affiliated with the French social security system may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of stroke in patients with atrial fibrillation who cannot tolerate long-term anticoagulation.
How similar studies have performed: Other studies have shown promising results with left atrial appendage closure, indicating that this approach is gaining traction in clinical practice.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Any patient for whom an indication has been made for implantation of a device for the closure of the left atrial appendage without restriction of indication and regardless of the outcome of the procedure (implantation success or not) Exclusion Criteria: * Refusal of the patient to participate in this study * Minor patient * Patient not affiliated to the French social security system
Where this trial is running
Créteil
- Assistance Publique Hôpitaux de Paris - CHU HENRI MONDOR — Créteil, France (Recruiting)
Study contacts
- Study coordinator: Emmanuel Teiger, MD, PhD
- Email: emmanuel.teiger@aphp.fr
- Phone: 00 33 1 49 81 22 51
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.