Closed blood sampling devices for adult ICU patients
Official title: Effectiveness of Closed-blood Sampling Devices in the Adult Critically Ill Patient: Multicenter Randomized Clinical Trial
Run by University of Barcelona · NCT06478160 · Data updated 2026-11-12
We will try closed‑blood sampling devices to see if they reduce the amount of blood taken for lab tests and lower the need for red‑blood‑cell transfusions in adults in the ICU who have arterial catheters.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 216 (estimated) |
| Sponsor | University of Barcelona Academic / other |
| Locations | 3 sites (Madrid, Madrid and 2 other locations) |
| Status | Recruiting |
| Started | November 11, 2024 |
| Main results expected | June 7, 2026 |
| Study ends | June 7, 2026 |
| Registry record updated | November 10, 2025 |
| Trial ID | NCT06478160 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adult ICU patients with an arterial catheter who have been in the unit for 24 hours and are expected to retain the catheter for at least 72 more hours, who meet inclusion criteria and consent, are eligible.
✕Probably not a fit
Patients with chronic renal failure, active gastrointestinal bleeding, hematologic malignancies, women menstruating at admission, pregnant women, Jehovah's Witnesses, or those who develop active GI bleeding during the study are excluded or unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with an arterial catheter who have been in the ICU 24 hours and are expected to keep the catheter for at least 72 more hours are randomized to either a closed‑blood sampling device (CBSD) or the usual open sampling with waste discard volume. In the CBSD group the device is attached and all arterial samples are drawn through it; in the control group the ICU's standard open extraction system is used and the discard volume is recorded. Investigators record the volume of blood drawn for laboratory tests, red blood cell transfusions, and arterial catheter‑related adverse events daily during ICU stay for up to 21 days or until discharge or death. Patients discharged to the ward are followed for 48 hours to capture any transfusions after ICU transfer.
Why it matters
Potential benefit: If successful, this approach could reduce diagnostic blood loss, lower the number of red‑cell transfusions, and possibly decrease catheter‑related complications for ICU patients.
How similar studies have gone: Previous studies of closed blood‑sampling devices have generally shown reduced diagnostic blood loss and, in some cases, fewer transfusions, though results vary and evidence is not uniformly definitive.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients with an arterial catheter who agree to participate in the study, with a stay in the ICU of 24h and a minimum of 72h more with an arterial catheter Non-inclusion criteria: Therapeutic Limitation of Life Support, Jehovah's Witnesses. Exclusion Criteria: * Patients with chronic renal failure * Patients with active gastrointestinal bleeding * Patients diagnosed with hematologic cancer * Women with menstruation at the time of admission * Pregnant women Withdrawal criteria: presence of active gastrointestinal bleeding during the study inclusion period.
Where it's running
-
Hospital Rey Juan Carlos
Madrid, Madrid, Spain Recruiting -
Hospital Virgen de la Macarena
Seville, Sevilla, Spain Recruiting -
Hospital Universitario 12 de Octubre
Madrid, Madrid, Spain Completed
Study contacts
- Principal investigator: Raurell-Torreda Marta — University of Barcelona
- Study coordinator: Raurell-Torreda Marta, PhD
- Email: mraurell@ub.edu
- Phone: 626154955
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Hands-on nutrition demonstrations added to the Diabetes Prevention Program for people with prediabetes
This project will test whether adding a 7-week series of healthy cooking and nutrition demos to the Diabetes Prevention Program helps adults at risk for prediabetes stay engaged and put healthy eating into daily life.
-
Group intervention to promote health-related habits
This study tests a group program that helps people with neurodevelopmental disorders and their families improve their health habits and overall well-being.
-
Improving nutrition and health services for women and children in rural communities
This study is testing a program that aims to improve nutrition and health services for women and children in rural areas of Bangladesh, Kenya, and Tanzania to see if it helps them grow healthier and empowers women.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.