Clopidogrel versus aspirin to lower cardiovascular and infection complications in people with Staphylococcus aureus bloodstream infection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This open-label, randomized trial enrolls patients with S. aureus bacteremia who are already on aspirin for secondary cardiovascular prevention and randomizes them to either continue aspirin or switch to clopidogrel. The trial compares clinical outcomes between the two antiplatelet strategies while following the SNAP platform protocols. Clopidogrel is of interest because laboratory and mechanistic data suggest it may have activity against S. aureus or modify host responses to infection. The study is a Phase 4 sub-study of the SNAP adaptive platform and, if findings are promising, could inform a larger Phase 3 trial in patients without a current indication for clopidogrel.

Why it matters

Who can join: the full rules

The participant must meet all inclusion and exclusion criteria for the SNAP

Platform (NCT05137119) and also the following inclusion and exclusion criteria:

Inclusion Criteria:

* Patient is taking aspirin for secondary prevention of cardiovascular disease (coronary, cerebrovascular, or peripheral vascular disease)

Exclusion Criteria:

* Active bleeding (allowing up to 3 days from platform entry to randomize in the event anti-thrombotic therapy is resumed)
* Anticipated major cardiac surgery, neurosurgery, or spine surgery within the next 3 days
* Pregnancy or lactation
* Known receipt of clopidogrel, prasugrel, or ticagrelor within the last month
* Allergy to clopidogrel
* Concomitant receipt of oral Xa inhibitor or dabigatran

Where it's running

• NL and Labrador Health Services- Health Sciences Centre
  St. John's, Newfoundland and Labrador, Canada Recruiting
• NL and Labrador Health Services- St. Clare's Mercy Hospital
  St. John's, Newfoundland and Labrador, Canada Recruiting
• McGill University Health Centre (Royal Victoria Hospital and Montreal General Hospital)
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Todd C Lee, MD MPH FIDSA — Research Institute of the McGill University Health Centre
• Study coordinator: Fatima Amari
• Email: fatima.amari@rimuhc.ca
• Phone: 5149341934

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Switching to dabigatran versus staying on apixaban/edoxaban/rivaroxaban for S. aureus bloodstream infection

  This trial will try whether switching people with S. aureus bloodstream infection who are already taking apixaban, edoxaban, or rivaroxaban to dabigatran leads to better outcomes.

  Recruiting at 3 sites Phase 4 McGill University Health Centre/Research Institute of the McGill University Health Centre · St. John's, Newfoundland and Labrador and 2 other locations · NCT06650501

• Comparing Daptomycin and Vancomycin for MRSA Bloodstream Infections

  This study is testing whether daptomycin or vancomycin works better for treating bloodstream infections caused by MRSA in patients.

  Recruiting at 20 sites Phase 4 McGill University Health Centre/Research Institute of the McGill University Health Centre · Blacktown, New South Wales and 19 other locations · NCT06637332

• Combining two antibiotics to treat Staphylococcus aureus bacteremia

  This study is testing if using two antibiotics together can help adults with Staphylococcus aureus bacteremia get better faster than the usual treatment.

  Recruiting at 8 sites Phase 2 McGill University Health Centre/Research Institute of the McGill University Health Centre · Calgary, Alberta and 7 other locations · NCT04886284

• Linezolid added to standard care for Staphylococcus aureus bloodstream infection

  This trial will test whether giving linezolid in addition to usual antibiotics helps adults hospitalized with Staphylococcus aureus bloodstream infections.

  Recruiting at 12 sites University Hospital, Basel, Switzerland · Aarau, Canton of Aargau and 11 other locations · NCT06958835

• Comparing two antibiotics for treating Staphylococcus aureus bloodstream infections

  This study is testing whether benzylpenicillin works better than cloxacillin for treating bloodstream infections caused by Staphylococcus aureus in adults.

  Recruiting Phase 4 Region Skane · Lund · NCT06726395

• Using clindamycin to improve treatment of skin infections caused by Staphylococcus aureus

  This study is testing if adding clindamycin to regular treatment can help adults in Sierra Leone recover faster from skin infections caused by Staphylococcus aureus.

  Recruiting Phase 4 Universität Münster · Masokori · NCT05899140

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.