Clinical features and molecular drivers of obstructive sleep apnea
Clinical Characteristics and Molecular Mechanism of Patients With Obstructive Sleep Apnea
Capital Medical University · NCT07277608
This project will collect clinical and molecular data from people with obstructive sleep apnea to see how disease severity affects prognosis, immunity, and metabolism.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Sex | All |
| Sponsor | Capital Medical University (other) |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT07277608 on ClinicalTrials.gov |
What this trial studies
This observational project will enroll patients with suspected obstructive sleep apnea at the sleep center of Beijing Chaoyang Hospital and build a multi-omics database from clinical data and biological samples. Investigators will compare immune, metabolic, and outcome patterns across different OSA severity levels and follow participants for at least one year to document prognosis, complications, and comorbidities. The study aims to track immune and metabolic dynamics after treatment and to identify biomarkers and potential therapeutic targets associated with OSA. Participants must consent to sample collection and follow-up, while those with major organ failure, pregnancy/lactation, or inability to comply with follow-up are excluded.
Who should consider this trial
Good fit: Ideal candidates are adults with suspected or confirmed obstructive sleep apnea seen at Beijing Chaoyang Hospital's sleep center who can consent and commit to at least one year of follow-up and sample collection.
Not a fit: Patients who are pregnant or lactating, have severe organ failure, require mechanical ventilation, are already unable to comply with follow-up, or refuse biological sampling are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the work could identify biomarkers and targets that improve prognosis prediction and enable more personalized treatment for people with OSA.
How similar studies have performed: Previous studies using molecular and metabolic profiling have shown associations between OSA and immune/metabolic changes, but comprehensive multi-omics biomarker panels for prognosis remain largely unproven.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with suspected obstructive sleep apnea (OSA) admitted to the sleep center of the respiratory Department of Beijing Chaoyang Hospital, Capital Medical University. * Volunteer to participate in the study and sign an informed consent, and can complete at least 1 year of follow-up. Exclusion Criteria: * Patients with obstructive sleep apnea who have been treated with impermanent positive pressure ventilation; * Pregnant or lactating women; * Patients with severe respiratory failure requiring mechanical ventilation; * Patients with severe heart, lung, liver, kidney, and central nervous system damage; * Refuse to participate in follow-up visits and/or take biological samples.
Where this trial is running
Beijing, Beijing Municipality
- Beijing Chaoyang hospital affiliated to Capital Medical University — Beijing, Beijing Municipality, China (RECRUITING)
Study contacts
- Study coordinator: Zhiling Zhao
- Email: cysleep@163.com
- Phone: +86 186 1280 8859
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Obstructive Sleep Apnea