Clinical and biological data collection for metastatic lung cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective cohort enrolls first-line metastatic or locally advanced lung cancer patients and collects detailed clinical, epidemiological, psychological, imaging, biological and biopathological data, including a biopsy of metastatic lesions. Patients are categorized by histology and PD-L1/immunohistochemistry phenotypes (including SCLC and NSCLC subtypes) and receive standard-of-care systemic treatments guided by current national recommendations. Multi-omic analyses and in silico modeling will be applied to the integrated dataset to develop algorithms aimed at predicting treatment response and mechanisms of resistance. The study combines routine care data with research assays and patient questionnaires at two regional cancer centers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Written informed consent obtained from the patient prior to performing any protocol-related procedures, including screening biopsy, blood sample and questionnaires
* 18 years old at time of written consent
* Patient with histologically confirmed lung cancer
* Lung cancer metastatic disease or locally advanced not eligible for local curative treatment intent
* Performance status ≤ 2 (according to WHO criteria)
* Indication of any systemic therapeutic strategy can be performed alongside this current cohort in accordance with national and / or international recommendations.
* Patient is willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up.
* Patient must be affiliated to a Social Health Insurance

Exclusion Criteria:

* Other malignancy treated within the last 3 years (except non-melanoma skin cancer or in situ carcinoma of the cervix)
* Other neuroendocrine tumour than small cell or large cell carcinoma.
* Pregnant or nursing patient
* Individual deprived of liberty or placed under the authority of a tutor
* Impossibility to submit to the medical follow-up of this clinical trial for geographical, social or psychological reasons

Where it's running

• Institut de Cancerologie de L'Ouest
  Angers, France Recruiting
• Institut de Cancerologie de L'Ouest
  Saint-Herblain, France Recruiting

Study contacts

• Principal investigator: Judith Raimbourg, Md,phd — judith.raimbourg@ico.unicancer.fr
• Study coordinator: Judith Raimbourg, Md,phd
• Email: judith.raimbourg@ico.unicancer.fr
• Phone: 0240679900

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.