Classifying common salty condiments by heart risk (natremic index)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants will consume a standardized porridge prepared four ways (no condiment, light soy sauce, fermented bean paste, and table salt) while researchers measure acute cardiovascular and physiological responses and sensory perception. The study links immediate blood-pressure and other cardiovascular responses to the sensory and compositional differences between condiments. Those data will be used to develop a natremic index that classifies sodium-rich condiments by their potential CVD-related risk, taking into account perceived saltiness and possible protective bioactive compounds. Enrollment targets men or postmenopausal women aged 50–74 with mildly elevated blood pressure and intact taste discrimination while excluding people with major metabolic, hepatic, renal, hematologic conditions or on interfering medications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. ≥ 50, \< 75 years old
2. Male or postmenopausal female (self-reported)
3. ≥ 50 kg body weight
4. Systolic blood pressure (≥ 130, \< 160 mmHg) or diastolic blood pressure (≥ 85, \< 100 mmHg)
5. Willing and able to follow intervention protocol
6. Ability to identify basic tastes (determined by taste discrimination test)
7. English speaking

Exclusion Criteria:

1. Prescribed and taking medication which may affect study outcomes (i.e. for blood pressure management, blood thinning etc.) in consultation with study physician (Prof Melvin Leow) and PI(Dr Darel Toh)
2. Type 1 or type 2 diabetes mellitus (i.e. fasting blood glucose ≥ 7.0 mmol/L or HbA1c ≥ 6.5 %)
3. Taking dietary supplements which may affect study outcomes one month prior to their first visit in consultation with study physician, PI and study team
4. Obesity (BMI ≥ 27.5 kg/m2)
5. History or known present diagnosis of hematological (G6PD and coagulation disorders), hepatic (hepatitis B and C), renal, gastrointestional or other relevant disease / disorders which may affect the outcomes of interest in consultation with study physician, PI and study team
6. History of arteriovenous shunt or mastectomy
7. Women who are pregnant, lactating or planning pregnancy
8. History or present diagnosis of HIV and/or tuberculosis
9. History of severe vasovagal syncope (blackouts or near faints) following blood draw
10. Drug abuse within last 5 years
11. Excessive alcoholic beverage consumption \> 2 servings per day (1 serving defined as 360 mL beer, 150 mL wine or 45 mL distilled spirits)
12. Smoking (cigarette, e-cigarette, cigar, pipe, vape)
13. Engaging in habitual vigorous physical activity (as defined by physical activity questionnaire-PAR)
14. Allergic or intolerance to intervention foods.
15. Dislike or unwilling to consume intervention foods
16. Photophobic (sensitivity to intense lights and colours), particularly to intense red lights
17. Has sinus problems problems that affect taste and smell
18. Involvement in other clinical studies that may influence the outcome of the study
19. An ASTAR Staff.
20. A study team member or their immediate family member

Where it's running

• Clinical Nutrition Research Centre
  Singapore, Singapore Recruiting

Study contacts

• Study coordinator: Darel Toh, PhD
• Email: darel_toh@a-star.edu.sg
• Phone: 64074149

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.