Chlordecone exposure and prostate cancer in Martinique
LIEN ENTRE EXPOSITION A LA CHLORDECONE ET CANCER DE LA PROSTATE EN MARTINIQUE
This project will see if exposure to the pesticide chlordecone is linked to prostate cancer in men who live in Martinique.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3600 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | Male |
| Sponsor | Institut National de la Santé Et de la Recherche Médicale, France Government |
| Locations | 2 sites (Fort-de-France and 1 other locations) |
| Trial ID | NCT06773806 on ClinicalTrials.gov |
What this trial studies
This is an observational case-control study enrolling men newly diagnosed with prostate cancer and biopsy-negative control men identified over a three-year period in Martinique. Investigators will compare histories and measures of chlordecone and other pesticide exposure between cases and controls, and adjust for known risk factors such as age, family history, and ethnicity. Participants are adult men under 75 who have lived in Martinique for at least six months and are treated at local hospitals and clinics. Clinical data and biological samples will be collected through participating centers including the University Hospital of Martinique and Clinique Saint‑Paul.
Who should consider this trial
Good fit: Ideal candidates are men under 75 who live in Martinique at least six months and are either newly diagnosed with prostate cancer or have a negative prostate biopsy after elevated PSA, and who can give informed consent.
Not a fit: Men who do not live in Martinique, are over 75, have a prior prostate cancer diagnosis, or cannot provide consent are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the study could identify an environmental risk factor that helps guide prevention, screening priorities, and public health policies in Martinique.
How similar studies have performed: Previous epidemiological work in the French West Indies has shown unusually high prostate cancer rates and has suggested links to pesticide exposure including chlordecone, but definitive causal evidence remains limited.
Eligibility criteria
Show full inclusion / exclusion criteria
INCLUSION CRITERIA To take part in this research, participants must meet the following criteria: Patients/cases : * All men newly diagnosed with Prostate Cancer in Martinique during a three-year given period in all public and private services caring for patients with Prostate Cancer, identified via multidisciplinary consultation meetings. * Male adults under 75 years of age * Resident in Martinique for at least 6 months * Histologically confirmed (inclusion possible as soon as the result is known by the urologist) * Affiliated to a social security scheme or equivalent * Have signed a free and informed consent form Biopsy-negative" controls (Group 1 controls): * All men with a negative prostate biopsy following elevated Prostate Specific Antigen (PSA) assay (\> 2.5 ng/ml) within a 3-year period in all public and private services in Martinique identified via urologists or pathologists. * Male adults under 75 years of age * Resident in Martinique for at least 6 months * Frequency matched on age (+/- 5 years) to patients * Affiliated to a social security scheme or equivalent * Signed free and informed consent PSA-negative" controls (Group 2 controls): * All men with a PSA ⩽ 2.5 ng/ml within a 3-year period and less than 3 months identified via a survey institute * Male adults under 75 years of age * Resident in Martinique for at least 6 months * Frequency matched on age (+/- 5 years) against patients * Frequency matched on socio-professional category against men of the same age in Martinique (INSEE data) NON INCLUSION CRITERIA To take part in this research, participants must not meet the following criteria: * Be subject to a legal protection measure (safeguard of justice, curatorship or guardianship). * Inability to consent because does not speak French or Creole.
Where this trial is running
Fort-de-France and 1 other locations
- The private clinic "Clinique Saint-Paul" — Fort-de-France, Martinique (Not_yet_recruiting)
- University Hospital of Martinique (CHUM) — Fort-de-France, Martinique (Recruiting)
Study contacts
- Study coordinator: Florence MENEGAUX, MD, PhD
- Email: florence.menegaux@inserm.fr
- Phone: +33 1 45 59 51 53
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.