Chitosan cream versus silicone gel and olive oil for preventing hypertrophic scars

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a three-arm, single-blinded, randomized trial comparing chitosan cream, silicone gel, and olive oil applied twice daily for eight weeks starting on day 14 after wound closure. Participants are randomized to one of the three topicals, with standardized clinical photographs and scar assessments using the Patient & Observer Scar Assessment Scale (POSAS) version 3.0 at weeks 4, 12, and 24. The investigator assessing outcomes is blinded to allocation while patients apply the assigned product and report any side effects. The trial recruits adults with primary-intention surgical or traumatic scars of at least 3 cm from three Malaysian hospitals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with traumatic or surgical wounds which have healed by primary intention within 14 days
* Length of scar at least 3cm

Exclusion Criteria:

* Patients with seafood allergy
* Patients with scar from wounds that were complicated by infection or wound breakdown
* Patients who have undergone scar treatment by other modalities
* Patients with history of keloids / hypertrophic scars
* Pregnant patients

Where it's running

• Hospital Pakar Universiti Sains Malaysia
  Kubang Kerian, Kelantan, Malaysia Recruiting
• Hospital Raja Perempuan Zainab II
  Kota Bharu, Kelantan, Malaysia Not yet recruiting
• Hospital Kuala Lumpur
  Kuala Lumpur, Kuala Lumpur, Malaysia Not yet recruiting

Study contacts

• Study coordinator: Esther HM Tan, MBBS
• Email: esthertan@student.usm.my
• Phone: +6097673000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.