Chemotherapy followed by immunotherapy for advanced bladder cancer

Chemotherapy and Sequential Immunotherapy for Locally Advanced Urothelial Cancer: the CHASIT Study

This study is testing if giving chemotherapy followed by an immunotherapy called avelumab can help people with advanced bladder cancer before they have surgery to remove the tumor.

Quick facts

• Phase: PHASE2
• Study type: Interventional
• Enrollment: 64 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Erasmus Medical Center (other)
• Drugs / interventions: avelumab, chemotherapy, radiation, prednisone
• Locations: 4 sites (Nijmegen, Gelderland and 3 other locations)
• Trial ID: NCT05600127 on ClinicalTrials.gov

What this trial studies

This study focuses on patients with locally advanced urothelial carcinoma who will first receive 3-4 cycles of platinum-based chemotherapy. Following this, those with stable disease will be treated with 3 cycles of avelumab, an anti-PD-L1 immunotherapy. If there is no disease progression after the avelumab treatment, participants will undergo radical surgery to remove the primary tumor and affected lymph nodes. The aim is to evaluate the safety and effectiveness of this sequential treatment approach.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with histologically confirmed locally advanced urothelial carcinoma who have stable disease after initial chemotherapy.

Not a fit: Patients with non-urothelial carcinoma or those who have progressed after initial chemotherapy may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could improve outcomes for patients with advanced urothelial carcinoma by enhancing tumor response before surgery.

How similar studies have performed: Previous studies have shown promise in combining chemotherapy with immunotherapy for various cancers, suggesting potential success for this approach in urothelial carcinoma.

Eligibility criteria

Inclusion Criteria:

1. Age ≥ 18 years.
2. Have histologically confirmed urothelial carcinoma of the bladder, upper urinary tract or urethra; a maximum of 50% of aberrant histology is allowed.
3. Have clinical stage cT4NxM0 or cTxN1-N3M0 as assessed by bimanual examination under anaesthesia, CT scan, MRI scan or PET-CT scan.
4. Have at least stable disease after a minimum of 3 or a maximum of 4 cycles of induction chemotherapy with cisplatin / carboplatin + gemcitabine according to RECIST v1.1.
5. Are fit and willing to undergo radical surgery with removal of lymph node template including all affected lymph nodes and the primary tumor.
6. World Health Organisation performance status of 0-2.
7. Provide written informed consent.
8. Negative pregnancy test in women with childbearing potential.
9. Adequate bone marrow function, including:

   1. Absolute neutrophil count (ANC) ≥1,500/mm3 or 1.5 x 109/L;
   2. Platelets ≥100 x 109/L;
   3. Hemoglobin ≥5.6 mmol/L (may have been transfused).
10. Adequate renal function, defined as estimated creatinine clearance ≥30 mL/min as calculated by the CKD-EPI eGFR.
11. Adequate liver function, including:

    1. Total serum bilirubin \<1.5 x upper limit of normal (ULN);
    2. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \<2.5 x ULN.

Exclusion Criteria:

1. Predominant (\>50%) non-urothelial carcinoma histology in the diagnostic endoresection specimen of the bladder, urethra or upper urinary tract.
2. Any test for hepatitis B virus (HBV) or hepatitis C virus (HCV) indicating acute or chronic infection.
3. Have an estimated creatinin clearance as assessed by the CKD-EPI eGFR of \<30 ml/min.
4. Prior exposure to immune-mediated therapy with exclusion of Bacillus-Calmette Guérin intravesical instillations, including but not limited to other anti-CTLA-4, anti PD-1, anti PD-L1, or anti-PD-L2 antibodies.
5. Persisting toxicity related to prior chemotherapy (Grade \>2 NCI CTCAE v5.0).
6. A diagnosis of any other malignancy within 2 years prior to inclusion, except for adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the breast or of the cervix, low grade prostate cancer on surveillance without any plans for treatment intervention, or prostate cancer that has been adequately treated with prostatectomy or radiotherapy and currently with no evidence of disease.
7. ≤2 cycles of induction platinum-based chemotherapy received.
8. Progression of disease during or following induction platinum-based chemotherapy, as assessed by RECIST v1.1.
9. Distant metastatic disease.
10. Previous pelvic radiation therapy.
11. Breastfeeding women.
12. Bilateral upper urinary tract urothelial carcinoma.
13. Active autoimmune disease that might deteriorate when receiving an immunostimulatory agent. Patients with diabetes type I, vitiligo, psoriasis, or hypo- or hyperthyroid disease not requiring immunosuppressive treatment are eligible.
14. Any of the following in the previous 6 months: myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident, transient ischemic attack or symptomatic pulmonary embolism.
15. Active infection requiring systemic therapy.
16. Known severe hypersensitivity reactions to monoclonal antibodies (Grade 3), any history of anaphylaxis, or uncontrolled asthma (ie, 3 or more features of asthma symptom control per the Global Initiative for Asthma 2015).
17. Known prior or suspected hypersensitivity to avelumab.
18. Current use of immunosuppressive medication, EXCEPT the following:

    1. Intranasal, inhaled, topical steroids, or local steroid injections (eg, intra-articular injection);
    2. Systemic corticosteroids at (equivalent) doses of maximum 10 mg prednisone;
    3. Steroids as premedication for hypersensitivity reactions (eg, CT scan premedication).
19. Diagnosis of prior immunodeficiency or organ transplant requiring immunosuppressive therapy, or known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness.
20. Vaccination within 4 weeks of the first dose of study treatment and while on trial is prohibited except for administration of inactivate vaccines (for example, inactivated influenza vaccines) or mRNA vaccines (for example, COVID-19 vaccines).
21. Other severe acute or chronic medical conditions including colitis, inflammatory bowel disease, and pneumonitis; psychiatric condition including recent (within the past year) or active suicidal ideation or behaviour; or laboratory abnormality that may increase the risk associated with study participation or study treatment administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the patient inappropriate for entry into this study.

Where this trial is running

Nijmegen, Gelderland and 3 other locations

• Radboud UMC — Nijmegen, Gelderland, Netherlands (RECRUITING)
• Jeroen Bosch ziekenhuis — 's-Hertogenbosch, North Brabant, Netherlands (RECRUITING)
• Amphia ziekenhuis — Breda, North Brabant, Netherlands (RECRUITING)
• Erasmus MC — Rotterdam, South Holland, Netherlands (RECRUITING)

Study contacts

• Principal investigator: J L Boormans, MD PhD — Erasmus Medical Center
• Study coordinator: J L Boormans, MD PhD

Conditions: Urothelial Carcinoma, Chemotherapy, Immunotherapy, Safety, Pathological response