Chemoradiotherapy for elderly patients with esophagus cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the safety and effectiveness of chemoradiotherapy in elderly patients over 75 years with esophageal cancer who are unfit for surgery. It aims to determine the maximum tolerated doses of chemotherapy and radiotherapy components, using a combination of carboplatin and paclitaxel alongside external beam radiotherapy. The study is designed in two phases, with Phase I focusing on dose determination and Phase II assessing treatment outcomes. The approach is based on previous studies that suggest carboplatin and paclitaxel may be more effective than traditional chemotherapy regimens.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Esophageal cancer, squamous and adenocarcinoma types, T1-3, N0-1, M1a (TNM 6th),
* age \> 75 years,
* WHO status \< 2, Balducci 1, adequate bone marrow reserve, normal renal and hepatic function.

Exclusion Criteria:

* age \< 75 years

Where it's running

• Centre Hospitalier Universitaire de Besançon
  Besançon, France Recruiting

Study contacts

• Study coordinator: Jihane BOUSTANI, Dr
• Email: jboustani@chu-besancon.fr

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.