Checking how well laser speckle contrast imaging measures gum blood flow
Official title: Analysis of the Reliability and Validity of Laser Speckle Contrast Analysis for the Measurement of Gingival Vascularisation
Run by Universidad Complutense de Madrid · NCT07527351 · Data updated 2026-11-12
We will test whether laser speckle contrast imaging (LSCI) can reliably measure superficial gum blood flow in healthy adults and in people healing after periodontal or implant-related soft-tissue surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | Universidad Complutense de Madrid Academic / other |
| Locations | 1 site (Madrid, Madrid) |
| Status | Recruiting |
| Started | April 13, 2026 |
| Main results expected | May 20, 2026 |
| Study ends | May 20, 2026 |
| Registry record updated | April 22, 2026 |
| Trial ID | NCT07527351 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults (18+) who do not smoke and are in good systemic and periodontal health for the healthy-gingiva arm, or patients with previously documented closed mucogingival or palatal donor-site wounds with prior consent for the retrospective arm.
✕Probably not a fit
People who smoke, are pregnant, have taken anti-inflammatory medication within seven days, have had oral treatment within six months, or have poor systemic or periodontal health are unlikely to qualify or receive benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional project will use the PeriCam PSI NR LSCI device to acquire repeated, contact-free perfusion maps of superficial gingival tissues in adults. Measurements will be taken prospectively in healthy gingiva and retrospectively from documented mucogingival surgical wounds, including closed surgical sites and open palatal donor sites, to compare reproducibility across healing patterns. Standardized patient preparation and imaging protocols will be used while systematically testing the influence of beam angulation, lip retractors, mirror use, temperature, and heart rate on perfusion readings. The primary aim is to determine the reproducibility and validity of LSCI measurements to support its use for monitoring oral soft-tissue vascularization during healing.
Why it matters
Potential benefit: If successful, LSCI could give clinicians a fast, objective, non-contact way to monitor gum blood flow and healing, enabling earlier detection of healing problems and more tailored care.
How similar studies have gone: LSCI has been used successfully to measure superficial microcirculation in other medical fields, but its application to gingival perfusion and periodontal wound monitoring is relatively novel and not yet widely validated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 years or older * Non-smokers * Good systemic health * Good periodontal health * No current systemic medication * Good oral hygiene * For the retrospective surgical component: availability of previously documented clinical records from closed mucogingival surgical wounds or open palatal donor-site wounds, with prior consent allowing use of documented clinical material for research Exclusion Criteria: * Pregnancy * Use of anti-inflammatory medication within 7 days before evaluation * Oral treatment within 6 months before evaluation * For the prospective healthy-gingiva component: any condition not compatible with good systemic or periodontal health * For the retrospective surgical component: absence of adequate previously documented clinical records or absence of prior consent for research use of the documented material
Where it's running
-
Complutense University of Madrid
Madrid, Madrid, Spain Recruiting
Study contacts
- Principal investigator: Mariano Sanz Alonso, DMD, MD, PHD — Universidad Complutense de Madrid
- Study coordinator: Mariano Sanz Alonso, DMD, MD, PHD
- Email: marsan@ucm.es
- Phone: 913942021
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.