Clinical trial Recruiting at 2 sites Observational

Checking for airflow limitation in smokers attending cardiology clinics

Official title: A Multinational, Multicenter, Observational, Prospective Cohort Study for Assessing the Prevalence of Airflow Limitation in Outpatients With History of Smoking Attending Cardiology Clinics

Run by AstraZeneca · NCT07315958 · Data updated 2026-11-12

This project will test how common airflow limitation is among people aged 40 and older with at least 10 pack‑years of smoking who visit cardiology clinics in Turkey.

More Chronic Obstructive Pulmonary Disease trials

Quick facts

Study typeObservational
SexAll
Enrollment1000 (estimated)
SponsorAstraZeneca
Industry-sponsored
Locations2 sites (Ankara and 1 other locations)
StatusRecruiting
StartedOctober 8, 2025
Main results expectedApril 30, 2027
Study endsApril 30, 2027
Registry record updatedSeptember 21, 2026
Trial IDNCT07315958 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 40 or older who attend the participating cardiology clinics, have a smoking history of at least 10 pack‑years, can complete spirometry and the CAAT questionnaire, and provide written consent.

Probably not a fit

People with a prior diagnosis of asthma, those who used a bronchodilator for an acute respiratory infection before spirometry, younger non‑smokers, or patients who do not attend the participating cardiology clinics are unlikely to benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study screens cardiology outpatients aged 40 and above with a smoking history of at least 10 pack‑years using spirometry and the COPD Assessment Test (CAAT). Patients are recruited at participating cardiology clinics in Ankara and Istanbul, provide written consent, complete the questionnaire, and undergo spirometry unless excluded for asthma or recent bronchodilator use. The primary goal is to estimate the prevalence of undiagnosed airflow limitation among smokers seen in cardiovascular outpatient settings. Results will be compared with regional COPD prevalence data to determine whether cardiology clinics are high‑yield sites for case-finding.

Why it matters

Potential benefit: If successful, this could help clinicians find previously undiagnosed COPD in smokers seen at heart clinics so patients can get earlier treatment and support.

How similar studies have gone: Previous screening efforts in non‑pulmonary clinics have often found high rates of undiagnosed airflow limitation, so this approach is not entirely novel and has shown useful results in similar settings.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Patients aged 40 years or older.
2. Patients with a smoking history of 10 pack-years or more.
3. Patients willing and able to complete pulmonary function test, using a spirometer.
4. Patients who have provided written consent to participate in the study.
5. Patients attending cardiology clinics at the participating centers.
6. Patients willing and able to complete the CAAT questionnaire.

Exclusion Criteria:

A. Patients diagnosed with bronchial asthma. B. Patients who used a bronchodilator for an acute respiratory infection before performing spirometry.

Where it's running

  • Research Site
    Ankara, Turkey (Türkiye)
    Recruiting
  • Research Site
    Istanbul, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.