Checking for airflow limitation in smokers attending cardiology clinics
Official title: A Multinational, Multicenter, Observational, Prospective Cohort Study for Assessing the Prevalence of Airflow Limitation in Outpatients With History of Smoking Attending Cardiology Clinics
Run by AstraZeneca · NCT07315958 · Data updated 2026-11-12
This project will test how common airflow limitation is among people aged 40 and older with at least 10 pack‑years of smoking who visit cardiology clinics in Turkey.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | AstraZeneca Industry-sponsored |
| Locations | 2 sites (Ankara and 1 other locations) |
| Status | Recruiting |
| Started | October 8, 2025 |
| Main results expected | April 30, 2027 |
| Study ends | April 30, 2027 |
| Registry record updated | September 21, 2026 |
| Trial ID | NCT07315958 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 40 or older who attend the participating cardiology clinics, have a smoking history of at least 10 pack‑years, can complete spirometry and the CAAT questionnaire, and provide written consent.
✕Probably not a fit
People with a prior diagnosis of asthma, those who used a bronchodilator for an acute respiratory infection before spirometry, younger non‑smokers, or patients who do not attend the participating cardiology clinics are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study screens cardiology outpatients aged 40 and above with a smoking history of at least 10 pack‑years using spirometry and the COPD Assessment Test (CAAT). Patients are recruited at participating cardiology clinics in Ankara and Istanbul, provide written consent, complete the questionnaire, and undergo spirometry unless excluded for asthma or recent bronchodilator use. The primary goal is to estimate the prevalence of undiagnosed airflow limitation among smokers seen in cardiovascular outpatient settings. Results will be compared with regional COPD prevalence data to determine whether cardiology clinics are high‑yield sites for case-finding.
Why it matters
Potential benefit: If successful, this could help clinicians find previously undiagnosed COPD in smokers seen at heart clinics so patients can get earlier treatment and support.
How similar studies have gone: Previous screening efforts in non‑pulmonary clinics have often found high rates of undiagnosed airflow limitation, so this approach is not entirely novel and has shown useful results in similar settings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients aged 40 years or older. 2. Patients with a smoking history of 10 pack-years or more. 3. Patients willing and able to complete pulmonary function test, using a spirometer. 4. Patients who have provided written consent to participate in the study. 5. Patients attending cardiology clinics at the participating centers. 6. Patients willing and able to complete the CAAT questionnaire. Exclusion Criteria: A. Patients diagnosed with bronchial asthma. B. Patients who used a bronchodilator for an acute respiratory infection before performing spirometry.
Where it's running
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Research Site
Ankara, Turkey (Türkiye) Recruiting -
Research Site
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: AstraZeneca Clinical Study Information Center
- Email: information.center@astrazeneca.com
- Phone: 1-877-240-9479
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.