Characterizing tissue changes in gastric cancer lesions
Characterization of Tissue Biochemical Composition in Gastric Precancerous/Cancerous Lesions
NA · National University Hospital, Singapore · NCT05977478
This study is trying to see how tissue changes in stomach cancer and precancerous lesions can help us understand the disease better by analyzing samples taken during endoscopy.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | National University Hospital, Singapore (other) |
| Locations | 1 site (Singapore) |
| Trial ID | NCT05977478 on ClinicalTrials.gov |
What this trial studies
This study aims to analyze tissue samples from gastric precancerous and cancerous lesions, as well as adjacent normal mucosa, using advanced techniques such as mass spectrometry lipidomic and proteomic profiling. The goal is to identify biochemical composition changes and correlate these findings with histopathological results and Raman spectra obtained through the SPECTRA IMDx™ probe. Participants will undergo upper gastrointestinal endoscopy, where biopsies will be taken for analysis. The study is conducted at the National University Hospital in Singapore.
Who should consider this trial
Good fit: Ideal candidates are adults aged 21 and above with a history of gastric dysplasia or cancer, or those undergoing surveillance after previous gastric cancer treatment.
Not a fit: Patients with bleeding disorders, active bleeding, severe co-morbid conditions, or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic methods for gastric cancer, enabling earlier detection and better treatment strategies.
How similar studies have performed: While similar studies have explored tissue characterization, this specific approach utilizing SPECTRA IMDx™ for gastric lesions is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. They are aged 21 years and above 2. They will be undergoing upper gastrointestinal endoscopy for any of the following: 1. Current or known history of gastric dysplasia and gastric cancer, or 2. Endoscopic surveillance after previous endoscopic or surgical resection for gastric dysplasia or gastric cancer. 3. They must be mentally competent. 4. They must be willing and able to comply with all study procedures. Exclusion Criteria: 1. Subjects with bleeding disorders, such as haemophilia, in whom biopsies are contraindicated. 2. Subjects with active bleeding or coagulopathy precluding biopsies. 3. Pregnant subjects. 4. The subject with severe co-morbid illness, such as end-stage renal failure (ESRF), congestive cardiac failure (CCF) and advanced liver cirrhosis. 5. Subjects with other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may interfere with the interpretation of study results or would make the subject unsuitable for entry into the study
Where this trial is running
Singapore
- National University Hospital — Singapore, Singapore (RECRUITING)
Study contacts
- Principal investigator: Guowei Kim, MBBS — National University Hospital, Singapore
- Study coordinator: Guowei Kim, MBBS
- Email: guo_wei_kim@nuhs.edu.sg
- Phone: +65-67725555
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Gastric Cancer