Characterizing small molecules in the healthy human gut
Characterization of Small Molecule Profiles in the Healthy Human Gastrointestinal Tract
This study looks at the tiny molecules in the guts of healthy people to see how they interact with diet and medications, hoping to find patterns that could help us understand health better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Weizmann Institute of Science Academic / other |
| Locations | 1 site (Reẖovot) |
| Trial ID | NCT05951972 on ClinicalTrials.gov |
What this trial studies
This study assesses the small molecule profiles found in the gastrointestinal tract of healthy volunteers. It aims to understand the interactions between the host and microbiota, influenced by factors such as nutrition and medications. By analyzing stool samples, the study will develop a pipeline to integrate these profiles with various health-related features. The goal is to identify molecular patterns that could inform future investigations into dietary and health impacts.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18-70 with a normal BMI.
Not a fit: Patients with chronic diseases, food allergies, or those on certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of gut health and nutrition, leading to improved dietary recommendations.
How similar studies have performed: While studies on gut microbiota and small molecules are ongoing, this specific approach to characterizing small molecule profiles in healthy individuals is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Normal BMI * Age 18-70 Exclusion Criteria: * Known food allergies to the tested food items * Chronic constipation (less than one bowel movement every two days) * Chronic treatment with any drug upon enrolment. * The use of systemic antibiotics, probiotics, or proton pump inhibitors 3 months prior to enrollment. * Diagnosis of type 1 or type 2 diabetes. * Any chronic disease at the discretion of the study team- such as active or recent cancer, inflammatory bowel disease, systemic autoimmunity * Any psychiatric disorders * Alcohol or substance abuse * Gut-related surgery, including bariatric surgery, but not including previous appendectomy. * Pregnancy, breastfeeding, or fertility treatments 6 months prior to enrollment for female participants
Where this trial is running
Reẖovot
- Weizmann Institute of Science — Reẖovot, Israel (Recruiting)
Study contacts
- Study coordinator: Avner Leshem, MD
- Email: avner.leshem@weizmann.ac.il
- Phone: +97289524014
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.