Characterizing cells from musculoskeletal tissues to improve treatment for joint disorders
Isolation, Characterization and Evaluation of the Potential of TissuE-resideNt cElls From Waste Musculoskeletal and Associated Connective Tissues
This study is trying to understand the cells in muscles and joints to find better treatments for joint problems like arthritis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 742 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio Academic / other |
| Locations | 1 site (Milan) |
| Trial ID | NCT05471752 on ClinicalTrials.gov |
What this trial studies
This study focuses on isolating and characterizing tissue-resident cells from various musculoskeletal and associated connective tissues, such as cartilage and bone, to explore new treatment strategies for degenerative and inflammatory musculoskeletal diseases. The researchers will compare the isolated cells based on their phenotypic and functional characteristics after exposure to inflammatory elements and treatments. Additionally, the study aims to correlate the properties of these cells with the clinical profiles of patients undergoing elective surgeries, such as joint replacements or ligament repairs.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are scheduled for elective joint surgeries.
Not a fit: Patients under 18, those unable to provide informed consent, or those with certain viral infections will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment options for patients with musculoskeletal disorders.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in characterizing tissue-resident cells for therapeutic applications.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * males and females * 18 years old * patients undergoing elective surgery at IRCCS Istituto Ortopedico Galeazzi among which joint surgery (including hip or knee replacement), or anterior cruciate ligament (ACL) reconstruction or rotator cuff repair Exclusion Criteria: * age \< 18 years old * patients unable to sign the Informed Consent * positivity to virological test (HIV, HCV, HBV, TPHA)
Where this trial is running
Milan
- IRCCS Istituto Ortopedico Galeazzi — Milan, Italy (Recruiting)
Study contacts
- Study coordinator: Direzione Scientifica
- Email: direzionescientifica.iog@grupposandonato.it
- Phone: 00390266214048
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.