Characterizing acute HIV infection in high-risk individuals
Establish and Characterize an Acute HIV Infection Cohort in a High Risk Population
This study is trying to learn more about people with early HIV infection by looking at their health, behavior, and immune responses to help improve future treatments and vaccines.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 777 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | SEARCH Research Foundation Academic / other |
| Locations | 1 site (Bangkok, Bangkok) |
| Trial ID | NCT00796146 on ClinicalTrials.gov |
What this trial studies
This study aims to establish a cohort of individuals with acute HIV infection, focusing on their clinical, immunological, and virological characteristics. It will assess demographics, behavioral risk factors, neurocognitive function, and immune responses, as well as track sexual contacts for voluntary HIV counseling and testing. Participants will undergo regular follow-ups and blood testing to monitor their health and the progression of the infection. The findings will contribute to understanding HIV-1 immunopathogenesis and support future vaccine development.
Who should consider this trial
Good fit: Ideal candidates are individuals over 18 years old with a confirmed acute HIV-1 infection.
Not a fit: Patients with a history of medical or psychiatric disorders that could interfere with study adherence or those who are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of acute HIV infection and inform strategies for prevention and treatment.
How similar studies have performed: Other studies focusing on acute HIV infection have shown promise in understanding the disease, but this specific cohort approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age \>18 years old 2. Have protocol-defined acute HIV-1 infection (Tested 4th generation HIV EIA negative and NAT positive or tested 4th generation HIV EIA positive, negative by less sensitive EIA and NAT positive) 3. Understand the study and sign informed consent form. Persons who cannot read will have the consent form read to them by a study staff and they can give informed consent by using thumb print. 4. Availability for follow-up for the planned study duration Exclusion Criteria: 1. Persons who have a history of a medical or psychiatric disorder by investigator's interview and physical examination according to standard practices, that in the judgment of the investigator(s), would interfere with or serve as a contraindication to adherence to the study protocol or ability to give informed consent. 2. Female participants who are pregnant at the time of screening
Where this trial is running
Bangkok, Bangkok
- Institute of HIV Research and Innovation (IHRI) — Bangkok, Bangkok, Thailand (Recruiting)
Study contacts
- Study coordinator: Nittaya Phanuphak, MD, PhD
- Email: Nittaya.p@ihri.org
- Phone: 6621605371
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.