Changes in lung mucus thickness and stretchiness during mechanical ventilation
Study of the Variation in Viscoelastic Properties of Pulmonary Mucus in Patients Undergoing Mechanical Ventilation With or Without NIV
This will see if bedside measurements of how thick and stretchy lung mucus is can help diagnose or monitor ventilator-associated pneumonia in adults on mechanical ventilation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Intercommunal Aix-Pertuis Academic / other |
| Locations | 1 site (Aix-en-Provence, Recherche) |
| Trial ID | NCT07490028 on ClinicalTrials.gov |
What this trial studies
Using bedside micro-rheological tools, clinicians will measure viscoelastic properties of bronchial mucus collected by routine bronchial aspiration from adults receiving invasive mechanical ventilation. This observational project will compare mucus rheology with clinical signs, radiological findings, and lower respiratory tract microbiology to explore links with ventilator-associated pneumonia. Samples are collected as part of standard ICU care at CHI Aix-Pertuis and analyzed rapidly to identify candidate rheological markers. No investigational treatments are given; the focus is on characterizing mucus properties that might support earlier diagnosis or personalized management.
Who should consider this trial
Good fit: Adult (over 18), French-speaking patients hospitalized in the CHI Aix-Pertuis ICU who are receiving invasive mechanical ventilation and who do not object to participation.
Not a fit: Pregnant or breastfeeding women, persons under guardianship or deprived of liberty, and patients not on invasive mechanical ventilation are not eligible and are unlikely to benefit.
Why it matters
Potential benefit: If successful, this approach could enable earlier, more targeted treatment of ventilator-associated pneumonia and reduce unnecessary antibiotic use.
How similar studies have performed: Bedside micro-rheological analysis of mucus is a novel approach and there are no prospective studies showing specific rheological markers for predicting VAP to date.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (\> 18 years old) * Hospitalised in the intensive care unit of the CHIAP * Placed on mechanical ventilation, regardless of the length of hospitalisation before and after * French-speaking patients, able to understand the study information leaflet * No objection from the patient Exclusion Criteria: * Pregnant or breastfeeding women * Patients deprived of their liberty, under guardianship or curatorship
Where this trial is running
Aix-en-Provence, Recherche
- CHI Aix-Pertuis — Aix-en-Provence, Recherche, France (Recruiting)
Study contacts
- Study coordinator: Olivier BALDESI, Dr
- Email: obaldesi@ch-aix.fr
- Phone: +33442339812
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.