Cervical cancer screening using self-sampling in younger women in Ethiopia
Evaluation of an Human Papillomavirus (HPV) Based Screening Algorithm for Low and Middle Income Countries, by Self-sampling in Ethiopia
NA · Lund University · NCT05125380
This study tests a new way for younger women in Ethiopia to collect samples for cervical cancer screening at home to see if it works well and can be used more widely.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 1200 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Lund University (other) |
| Locations | 1 site (Ādama) |
| Trial ID | NCT05125380 on ClinicalTrials.gov |
What this trial studies
This project aims to evaluate a self-sampling algorithm for HPV-based cervical cancer screening in a mid-size town in Ethiopia, with the potential for nationwide implementation in low and middle-income countries. The study will assess the effectiveness of Visual Inspection with Acetic acid (VIA) and Lugol's Iodine (VILI) as triage methods, while also monitoring the prevalence of STIs such as Chlamydia and Gonorrhea. Additionally, it will explore immune response profiles in HPV-positive women and the relationship between cervicovaginal microbiota and cervical health outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are women over 18 years old who can provide consent and have not undergone a hysterectomy.
Not a fit: Women who have had a hysterectomy will not benefit from this study as they are excluded from participation.
Why it matters
Potential benefit: If successful, this study could significantly improve cervical cancer screening accessibility and outcomes for women in low and middle-income countries.
How similar studies have performed: Other studies have shown promise in using self-sampling for HPV screening, indicating that this approach could be effective in similar settings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Can give consent, Age above 18 Exclusion Criteria: * Women who have undergone hysterectomy
Where this trial is running
Ādama
- Adama and Geda Health Center — Ādama, Ethiopia (RECRUITING)
Study contacts
- Principal investigator: Adane Mihret, PhD — Armauer Hansen Research Institute
- Study coordinator: Selamawit Mekuria, MD
- Email: selamawit.mekuria@med.lu.se
- Phone: +46720123974
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cervical Cancer, STI, Human Papilloma Virus, Microbiota, LMIC Lowe Middle income country, Screening, Vaginal microbiota