Cerebrolysin's effects on language ability in stroke patients with non-fluent aphasia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of cerebrolysin on language ability in patients suffering from non-fluent aphasia following a stroke. Participants are divided into two groups: one receiving standard speech therapy combined with cerebrolysin, and the other receiving only standard speech therapy as a control. The study aims to measure changes in language ability using the PK-WAB scores before and after treatment. It focuses on patients in the subacute phase of stroke, where language therapy is crucial for recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients with a first-episodic of ischemic or hemorrhagic stroke
2. Patients with lesions in the left supratentorial area confirmed by CT or MRI
3. Subacute phase within one month of stroke onset
4. Aged between 19 and 90 years
5. Patients diagnosed with non-fluent aphasia through the Korean version of the Western Aphasia Battery
6. Right-handed individuals assessed by the Edinburgh Handedness Inventory
7. Individuals who voluntarily provided written consent for participation in the clinical trial, either personally or through their legal representative
8. Native speakers of Korean

Exclusion Criteria:

1. Individuals with contraindications, including allergies to cerebrolysin
2. Multiple previous episode of stroke that had been managed.
3. Presence of significant pre-existing neurogenic disorders
4. Presence of significant psychiatric disorders such as major depressive disorder, schizophrenia, bipolar disorder, or dementia
5. History of alcohol or other substance abuse within 3 years of onset
6. Presence of severe liver, kidney, heart, or respiratory diseases
7. Medical findings from diagnostic tests indicating any of the following conditions (Total serum bilirubin \> 4mg/dL, alkaline phosphatase \> 250 U/L, SGOT/AST \> 150 U/L. SGPT/ALT \> 150 U/L., or creatinine \>3.5 mg/dL)
8. Presence of an underlying medical condition with a life expectancy of less than 1 year
9. Pregnant or breastfeeding individuals
10. Participation in another therapeutic study

Where it's running

• Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine
  Seoul, South Korea Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.