Cerebellar tACS plus iTBS combined with exercise for ataxia balance

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study enrolls people with clinically confirmed ataxia to receive either real combined cerebellar transcranial alternating current stimulation (tACS) and intermittent theta burst stimulation (iTBS) plus guided exergaming or sham stimulation plus the same exergaming. Sessions pair non-invasive electrical and magnetic cerebellar stimulation with balance-focused exercise, and outcomes include clinical balance measures and neurophysiological markers such as motor-evoked potential (MEP) amplitudes. The design compares immediate and short-term changes between the real and sham groups to determine whether combined neuromodulation produces larger improvements than exergaming alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Confirmed diagnosis of ataxia based on clinical assessment and/or neuroimaging findings.
2. Stable medication regimen for at least four weeks prior to the study.
3. Sufficient cognitive ability to understand and comply with study instructions.

Exclusion Criteria:

1. History of seizures.
2. Severe general impairment or concomitant diseases.
3. Intracranial metal implants.
4. Cardiac pacemaker.
5. Pregnancy status.

Where it's running

• IRCCS Santa Lucia Foundation
  Rome, Lazio, Italy Recruiting

Study contacts

• Study coordinator: Giacomo Koch, Prof.
• Email: g.koch@hsantalucia.it
• Phone: 0651501181

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.