Cenerimod added to standard treatment for active lupus nephritis

A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Trial to Assess the Efficacy, Safety and Tolerability of Cenerimod in Adult Patients With Systemic Lupus Erythematosus and Active Lupus Nephritis in Combination With Background Therapy

This study will test whether taking cenerimod along with regular treatment helps adults with systemic lupus and active lupus nephritis improve their kidney function and is safe to use.

Quick facts

• Phase: Phase 3
• Study type: Interventional
• Enrollment: 300 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Viatris Inc. (Industry-sponsored)
• Drugs / interventions: belimumab, anifrolumab, rituximab, obinutuzumab, ocrelizumab, Alemtuzumab, Methotrexate, cyclophosphamide, prednisone
• Locations: 9 sites (Kissimmee, Florida and 8 other locations)
• Trial ID: NCT07201129 on ClinicalTrials.gov

What this trial studies

This Phase 3, randomized, placebo-controlled trial adds daily oral cenerimod or a matching placebo to participants' standard lupus nephritis therapy for 76 weeks. Eligible adults must have systemic lupus erythematosus by 2019 EULAR/ACR criteria and biopsy-confirmed active lupus nephritis with proteinuria and sufficient kidney function. Participants will be followed with clinic visits every 1 to 3 months for laboratory tests, kidney function monitoring, and safety assessments. The main outcomes are changes in kidney function and the type and frequency of adverse events while on cenerimod versus placebo.

Who should consider this trial

Good fit: Adults with systemic lupus erythematosus per 2019 EULAR/ACR criteria who have biopsy-confirmed class III/IV (with or without class V) or pure class V lupus nephritis, urine protein/creatinine ratio ≥1 mg/mg, and eGFR ≥15 mL/min/1.73 m² are ideal candidates.

Not a fit: Patients without biopsy-confirmed active lupus nephritis, with very low proteinuria, with advanced chronic kidney scarring, eGFR below study thresholds, or with disqualifying medical conditions (including pregnancy) are unlikely to benefit from participation.

Why it matters

Potential benefit: If successful, cenerimod added to standard therapy could improve kidney outcomes and reduce disease activity for adults with active lupus nephritis.

How similar studies have performed: S1P receptor modulators have shown benefit in other autoimmune diseases and early-phase studies of cenerimod demonstrated biological activity in systemic lupus, but its specific effect on lupus nephritis has not been established.

Eligibility criteria

Main Inclusion Criteria:

* Classification of systemic lupus erythematosus (SLE) made according to the 2019 European Alliance of Associations for Rheumatology / American College of Rheumatology (EULAR/ACR) criteria.
* Renal biopsy within 6 months prior to Screening visit indicating Class III or IV active glomerulonephritis with or without co-existing Class V, OR pure Class V membranous LN. If no biopsy was performed within 6 months of Screening, a biopsy will be performed during the Screening period, after all other inclusion/exclusion criteria are verified.
* Active renal disease defined as urine protein/creatinine ratio ≥ 1 mg/mg, assessed on a 24h urine collection.
* eGFR ≥ 15 mL/min/1.73 m\^2. Enrollment of participants with eGFR between ≥ 15 and \< 30 mL/min/1.73 m\^2 requires:

  * a renal biopsy during the screening period showing sclerosis in ≤ 50% of glomeruli,
  * activity index ≥ 2, and chronicity index \< 4, on the National Institutes for Health 2018 activity and chronicity indices. These indices must be assessed on the kidney biopsy dated less than 6 months prior to Screening and confirmed by a nephropathologist.
* Initiation of the induction therapy with the mandatory following background therapy:

  1. Mycophenolate mofetil 1-3 g/day orally or mycophenolate sodium 720-2160 mg/day orally at Randomization. This treatment can be in place before Screening or started at Screening.
  2. Corticosteroids: 1-3 intravenous (i.v.) pulses of methylprednisolone at 250 to 1000 mg/pulse/day (maximum cumulative 3000 mg) followed by oral prednisone (or equivalent) at 0.5 mg/kg/day with a cap at 40 mg/day. Pulses can be administered during screening and up to 2 weeks prior to screening. Participants who cannot take the pulse i.v. corticosteroid therapy should directly start on 0.8-1.0 mg/kg/day (max 80 mg/day) oral prednisone (or equivalent), within the same window as i.v. pulses.

Note: If treatment with an antimalarial or belimumab is taken, it must be initiated at least 4 weeks prior to Screening and must be at stable dose during these 28 days prior to Randomization and continued at a stable dose until End-of-Treatment. Participants on azathioprine must be switched to mycophenolate mofetil or mycophenolate sodium prior to Randomization.

* Participants of childbearing potential must agree to:

  * Use a highly effective method of contraception from the Screening visit up to at least 24 weeks after discontinuation of trial intervention.
  * Undertake monthly urine pregnancy tests during the trial and up to at least 24 weeks after discontinuation of trial intervention.

Main Exclusion Criteria:

* Severe active central nervous system lupus
* History of, or current renal diseases (other than LN) that, in the opinion of the investigator, could interfere with the LN assessment and confound the disease activity assessment (e.g., diabetic nephropathy), or require dialysis, transplantation or end-stage renal disease.
* History or presence of Mobitz type II or third-degree atrioventricular block, sick sinus syndrome, symptomatic bradycardia, or syncope associated with cardiac disorders.
* Participants who experienced myocardial infarction, unstable angina pectoris, stroke, transient ischemic attack, vascular thrombosis, decompensated heart failure requiring hospitalization, or heart failure defined by the New York Heart Association Class III/IV within 6 months prior to Screening.
* Resting heart rate \< 50 bpm as measured by the 12-lead electrocardiogram (ECG) at Screening or at Randomization.
* Diagnosis of active or latent tuberculosis at Screening or within 6 months prior to Screening
* Negative antibody test for varicella-zoster virus
* Positive results for serological markers for hepatitis A, B, C and E indicating acute or chronic infection
* Participants with a positive human immunodeficiency virus (HIV) test or who have any other congenital or acquired immunodeficiency
* Presence of any of the following abnormalities, detected during the ophthalmological evaluation and/or by optical coherence tomography, as evaluated by the site ophthalmologist, during Screening:

  * Macular edema of any cause: diabetic, cystoid, tractional.
  * Foveal degeneration: macular hole, macular pseudohole, hereditary or degenerative maculopathies.
  * Active uveitis, papilledema.
  * Retinal neovascularization of any cause and in any location.
* Significant hematology abnormality at Screening:

  * Hemoglobin \< 7 g/dL;
  * Lymphocyte count \< 500 /μL (0.5 × 10\^9/L);
  * White blood cell count \< 1500/μL (1.5 × 10\^9/L) or
  * Platelets \< 25,000/μL (25 × 10\^9/L)
* Treatment with the following medications within 5 half-lives of the medication prior to Randomization: Cyclosporine, voclosporin, tacrolimus, sirolimus, cyclophosphamide.
* Treatment with the following medications within 90 days prior to Randomization:

  * Leflunomide.
  * i.v. immunoglobulins.
  * Methotrexate.
  * Tyrosine kinase inhibitors.
* Treatment with anifrolumab within 6 months prior to Randomization.
* Treatment with biological immunosuppressive agents, (e.g., anti-tumor necrosis factor \[anti-TNF\], anti-interleukin-1 \[anti-IL1\], anti-IL6 therapies) within 90 days prior to Randomization.
* Treatment with B cell-depleting biological agents (e.g., rituximab, obinutuzumab or ocrelizumab) within 12 months prior to Randomization.
* Treatment with any of the following medications any time prior to Screening:

  * Alemtuzumab.
  * Sphingosine-1-phosphate receptor modulators (e.g., fingolimod).
  * Participants previously randomized to cenerimod or placebo in any trial involving cenerimod.
* Pregnancy confirmed via a serum pregnancy test at the Screening visit or a urine/serum pregnancy test at the Randomization visit or planning to become pregnant, or lactating participant.

Where this trial is running

Kissimmee, Florida and 8 other locations

• Alloy Clinical Research LLC — Kissimmee, Florida, United States (Recruiting)
• SouthCoast Research Center — Miami, Florida, United States (Recruiting)
• Allied Biomedical Research Institute — Miami, Florida, United States (Recruiting)
• DH NationalResearchCenters INC — Miami, Florida, United States (Recruiting)
• ProfessionalResearchCenter INC — Miami, Florida, United States (Recruiting)
• San Marcus Research Clinic, Inc. — Miami Lakes, Florida, United States (Recruiting)
• Rheumatology Care Center, PLLC — Bellaire, Texas, United States (Recruiting)
• Novel Research, LLC. — Houston, Texas, United States (Recruiting)
• Northwest Houston Arthritis — Houston, Texas, United States (Recruiting)

Study contacts

• Study coordinator: Viatris Innovation Clinical Trial Information

Conditions Nephritis, Lupus; Lupus Erythematosus, Systemic