Celiac plexus neurolysis with and without bupivacaine for pancreatic cancer pain relief

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of celiac plexus neurolysis (EUS-CPN) in patients with pancreatic cancer, comparing outcomes between those receiving the procedure with and without the local anesthetic bupivacaine. The study aims to determine if the inclusion of bupivacaine affects pain control during and after the procedure, as well as its potential risks. Participants will undergo EUS-guided injections of absolute alcohol around the celiac plexus to alleviate pain associated with their condition. The trial will help clarify the role of bupivacaine in this context, which has not been previously established.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Malignant-appearing pancreatic mass, or proven pancreatic cancer involving the pancreatic genu, body, or tail
2. Any level of abdominal or back pain considered to be potentially related to the mass:

   1. New onset pain (\<3 months)
   2. Constant
   3. Centrally located
   4. With or without irradiation to the back
   5. No obvious other source of pain based on history and physical examination by the attending endosonographer
3. No possibility of surgical management
4. Signed, informed consent
5. Celiac axis accessible for bilateral neurolysis at EUS.

Exclusion Criteria:

1\. Allergy to bupivacaine

Where it's running

• Centre de recherche du Centre hospitalier de l'Université de Montréal
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Anand V Sahai, Md — Centre de Recherche du Centre Hospitalier de l'Université de Montréal
• Study coordinator: Charles Mackay, Rn
• Email: charles.mackay.chum@ssss.gouv.qc.ca
• Phone: 514-890-8000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.