CBCT-guided offline adaptive radiotherapy for advanced non-small-cell lung cancer
Efficiency of Contemporary Off-line Adaptive Radiotherapy for Lung Cancer
NA · Universitaire Ziekenhuizen KU Leuven · NCT07259447
This project will try using cone-beam CT scans taken during treatment to adapt radiotherapy plans for people with locally advanced non-small-cell lung cancer.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Sex | All |
| Sponsor | Universitaire Ziekenhuizen KU Leuven (other) |
| Drugs / interventions | radiation, immunotherapy |
| Locations | 1 site (Leuven, Vlaams-Brabant) |
| Trial ID | NCT07259447 on ClinicalTrials.gov |
What this trial studies
This single-center interventional protocol at UZ Leuven tests an offline adaptive radiotherapy workflow that uses routinely acquired cone-beam CT (CBCT) images to update treatment plans during the course of radiotherapy for locally advanced NSCLC. The approach aims to avoid repeated planning CT scans by leveraging improved CBCT image quality together with automated contouring and knowledge-based planning to streamline plan adaptation. Patients receiving sequential or concurrent chemoradiotherapy will have regular dosimetric reviews and plan adaptations if CBCT-based assessments show clinically relevant changes in tumor or organ-at-risk geometry. The trial captures feasibility, dosimetric effects on target coverage and organs at risk, and workflow efficiency metrics.
Who should consider this trial
Good fit: Adults with locally advanced (stage III or higher) non-small-cell lung cancer planned for sequential or concurrent chemoradiotherapy who can undergo CBCT imaging and provide informed consent are eligible.
Not a fit: Patients with early-stage NSCLC, small-cell lung cancer, mesothelioma, those not receiving chemoradiotherapy, or those unable to undergo CBCT imaging are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, this approach could maintain or improve tumor control while reducing extra planning CT scans and treatment-planning workload, potentially lowering normal-tissue doses and side effects.
How similar studies have performed: Adaptive radiotherapy has shown promise in prior studies for improving dosimetry and possibly outcomes, but CBCT-only off-line adaptation workflows remain relatively novel and lack large multicenter confirmation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures 2. Patients diagnosed with non-small-cell lung cancer 3. Locally advanced disease (≥Stage III) 4. Treated with sequential or concurrent chemoradiotherapy Exclusion Criteria: 1. Small-cell lung cancer 2. Non-small-cell lung cancer of early stage 3. Mesothelioma
Where this trial is running
Leuven, Vlaams-Brabant
- UZ Leuven — Leuven, Vlaams-Brabant, Belgium (RECRUITING)
Study contacts
- Study coordinator: Wouter Crijns, Prof. Dr.
- Email: wouter.crijns@uzleuven.be
- Phone: +3216341453
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: NSCLC, Adaptive Radiotherapy, CBCT-based Adaptive Radiotherapy