Causes and outcomes of freezing of gait in Parkinsonian conditions
FREEZE-Path Cohort: Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)
This registry will collect long-term clinical, gait, and video data from adults with freezing of gait or related parkinsonian conditions to see if different causes lead to distinct symptoms, walking patterns, falls, and disease progression.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 700 (estimated) |
| Ages | 30 Years to 85 Years |
| Sex | All |
| Sponsor | Tianjin Huanhu Hospital Academic / other |
| Locations | 1 site (Tianjin, Tianjin Municipality) |
| Trial ID | NCT07386015 on ClinicalTrials.gov |
What this trial studies
This is a prospective, observational patient registry led by Tianjin Huanhu Hospital that enrolls adults with freezing of gait, gait and balance impairment, or those at high risk for FOG. Participants receive usual clinical care while study staff collect baseline and scheduled follow-up data including questionnaires, standardized gait and balance tasks, objective gait parameters, falls history, and video and speech recordings. No experimental treatments are assigned; data are recorded during routine visits and follow-up assessments. The registry aims to link underlying causes (Parkinson's disease and other parkinsonian syndromes) to clinical phenotypes, gait signatures, and long-term outcomes.
Who should consider this trial
Good fit: Adults aged 30-85 with freezing of gait or non-freezing gait/balance impairment and a diagnosis of Parkinson's disease or a related parkinsonian disorder who can complete gait and balance tasks and provide informed consent.
Not a fit: Patients with severe dementia, severe psychiatric or medical conditions affecting gait safety, recent major medical events, inability to comply with follow-up, or refusal of video/speech recording may be ineligible or unlikely to benefit directly from this registry.
Why it matters
Potential benefit: If successful, the registry could help clinicians identify who is at higher risk of falls or rapid progression and guide more personalized management of gait problems.
How similar studies have performed: Previous observational cohorts and smaller registries have described clinical patterns and risk factors for FOG, but comprehensive long-term, multi-diagnostic registries remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 30-85 years 2. Presence of freezing of gait or non-freezing gait or balance impairment 3. Diagnosis of Parkinson's disease or related parkinsonian disorders according to established international criteria (including PD, PSP, MSA, DLB, CBD, vascular parkinsonism, or idiopathic normal pressure hydrocephalus) 4. Ability to complete gait and balance assessment tasks independently or with assistance 5. Ability and willingness to provide written informed consent Exclusion Criteria: 1. Severe dementia (Mini-Mental State Examination score \< 10) 2. Severe psychiatric disorders interfering with study participation 3. Severe cardiopulmonary, musculoskeletal, or other medical conditions significantly affecting gait safety 4. Stroke, fracture, or other major medical events within the past 3 months 5. Inability to comply with follow-up procedures 6. Refusal of video or speech data collection
Where this trial is running
Tianjin, Tianjin Municipality
- Tianjin Huanhu Hospital — Tianjin, Tianjin Municipality, China (Recruiting)
Study contacts
- Principal investigator: Peipei Liu, MD — Tianjin Huanhu Hospital
- Study coordinator: Peipei Liu, MD
- Email: pddoctorpipi2021@163.com
- Phone: 86-13512204476
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.