Catheter ablation treatment for people with atrial fibrillation
Official title: A Prospective Cohort Study of Atrial Fibrillation Patients Treated With Catheter Ablation
Run by Peking Union Medical College Hospital · NCT05266144 · Data updated 2026-11-12
This project will try radiofrequency catheter ablation in adults with non-valvular atrial fibrillation to see if it improves atrial function and quality of life and to identify who is likely to have recurrence.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Peking Union Medical College Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | September 4, 2020 |
| Main results expected | October 1, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | November 3, 2026 |
| Trial ID | NCT05266144 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 with non-valvular paroxysmal or persistent atrial fibrillation, a left atrial anteroposterior diameter <50 mm, and who are eligible and consenting for bilateral pulmonary vein isolation are ideal candidates.
✕Probably not a fit
People with valvular atrial disease, prior AF ablation, active hyperthyroidism, intra-atrial thrombus, or those outside the specified age or left atrial size limits are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center prospective observational cohort will follow adults with non-valvular atrial fibrillation who undergo radiofrequency catheter ablation at Peking Union Medical College Hospital. Researchers will collect baseline clinical data and measure serologic markers of atrial fibrosis, transthoracic echocardiography, cardiac MRI, atrial potential mapping, quality-of-life questionnaires, and long-term ECG monitoring within one week after ablation. They will use these multidimensional data to build a predictive model for atrial fibrillation recurrence after ablation and analyze relationships between noninvasive measures of fibrosis, atrial electrical activity, and atrial function. Patients with evidence of ventricular fibrosis will be selected for gene sequencing to search for underlying cardiomyopathy and to provide data for further research.
Why it matters
Potential benefit: If successful, the work could help predict which patients are most likely to have AF recurrence after ablation and guide more personalized follow-up and treatment.
How similar studies have gone: Radiofrequency ablation is an established treatment with many studies showing clinical benefit, but combining imaging, serologic fibrosis markers, electrical mapping, and genomics to predict recurrence is a relatively novel, emerging approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Non-valvular atrial fibrillation, including paroxysmal atrial fibrillation and persistent atrial fibrillation * 18-80 years old * The anteroposterior diameter of the left atrium is less than 50mm via TTE * Patient meets the intervention criteria for bilateral pulmonary vein isolation after evaluation by electrophysiological specialists * Patient consents to ablation treatment Exclusion Criteria: * Intra-atrial thrombus detected by TEE * Hyperthyroidism * Previous radiofrequency ablation for atrial fibrillation
Where it's running
-
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Principal investigator: Yongtai Liu, M.D. — Peking Union Medical College Hospital
- Study coordinator: Yongtai Liu, M.D.
- Email: ataiever@163.com
- Phone: +86-1069155068
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.