Carrot juice for preventing colorectal cancer in high-risk patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective randomized double-blinded study aims to evaluate the prophylactic effects of carrot juice rich in polyacetylenes on patients who have undergone resection of high-risk colorectal adenomas. Participants will consume 100 ml of either active carrot juice or placebo daily for one year, while their compliance will be monitored through diaries. The study will compare the incidence and growth of recurrent adenomas between the two groups to determine if the carrot juice significantly reduces neoplastic transformation. The trial is conducted across multiple centers in Denmark and Sweden.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Any type of resection for adenomas larger than 20 mm in size (endoscopically evaluated) or endoscopically resected T1 cancers.
2. Acceptance of the treatment and follow-up program.
3. Capability to understand and follow the instructions.

Exclusion Criteria:

1. Patients allocated to "high-risk" group because of many small polyps (\>4).
2. Pregnancy.
3. Known relevant allergies.
4. Chronic consumption of COX (cyclooxygenase) inhibitors (Aspirin, Celecoxib, Ibuprofen, Diclofenac, Ketoprofen, Ketorolac, Indometacin, Naproxen, Piroxicam) or immunosuppressive agents (Methotrexate, Azathioprine or glucocorticoids).
5. Patients with different neoplastic disease under treatment (Chemo-/Radio-/Imunotherapy).
6. Severe comorbidity NYHA III-IV.
7. Lynch syndrome.

Where it's running

• Department of Surgery, Odense University Hospital
  Odense, Denmark Recruiting

Study contacts

• Principal investigator: Gunnar Baatrup, Professor — OUH og Svendborg Sygehus
• Study coordinator: Gunnar Baatrup, Professor
• Email: Gunnar.Baatrup@rsyd.dk
• Phone: +4520575154

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.