Care for young adults with relapsing-remitting MS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The project uses community-based participatory research to develop culturally tailored measures of childhood adversity for people with MS. In a cross-sectional arm, eligible young adults with relapsing-remitting MS will attend two visits including a research blood draw and MRI to examine relationships between adversity and clinical, imaging, and laboratory outcomes. A subset of participants will complete interviews and surveys to explore environmental and social factors that affect quality of life among minority and underrepresented MS patients. The work is conducted across multiple U.S. academic sites with involvement from a federal neurological institute.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Aim 1 -

* aged ≥18-29 years
* diagnosis of RRMS (Fulfill international criteria for relapsing remitting (RRMS))
* 70% self-identifying as a Black, Hispanic, or poverty-impacted (up to 138% of the federal poverty level) individual,and
* fluent in English or Spanish.

Aim 2 -

* aged ≥18-29 years
* diagnosis of RRMS (Fulfill international criteria for relapsing remitting (RRMS))
* 70% self-identifying as a Black, Hispanic, or poverty impacted, and
* fluent reading in English or Spanish
* Pediatric onset MS (MS onset before age 18 and age at time of enrollment is 18-25) OR adult-onset MS (MS onset at age 18 or older and age at time of enrollment is 19-29)
* Disease duration below 8 years

Aim 3 -

Aim 3 will enroll the first 20 participants from Aim 2 who meet the following criteria:

* completed at least 80% of study data in the cross-sectional study/Aim 2.
* a total of 70% must self-identify as Black, Hispanic, or meet criteria for poverty impacted.
* interviews will be evenly split between participants with high (top quartile) and low (bottom quartile) of PROMIS-10 scores.

Exclusion Criteria:

* Primary or Secondary Progressive MS
* Inability to consent.
* MS relapse within 30 days prior to study entry
* Other major neurologic or psychiatric illness

Where it's running

• University of Alabama at Birmingham
  Birmingham, Alabama, United States Recruiting
• University of California, San Francisco
  San Francisco, California, United States Recruiting
• University of Colorado Denver
  Aurora, Colorado, United States Recruiting
• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting
• Cleveland Clinic
  Cleveland, Ohio, United States Recruiting
• Baylor College of Medicine
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Lauren Krupp, MD — NYU Langone Health
• Study coordinator: Taj Adams
• Email: Taj.Adams@nyulangone.org
• Phone: 646-501-7528

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.