Clinical trial Recruiting at 1 site Interventional Ages 46 to 65 Women only

Cardiometabolic effects of different endurance-plus-resistance exercise prescriptions in postmenopausal women

Official title: Cardiometabolic Adaptations to Resistance and Endurance Exercise: Effects of Effort Configuration in Concurrent Training for Postmenopausal Women

Run by Universidade da Coruña · NCT07377383 · Data updated 2026-11-12

This 20-week program tests whether different ways of combining endurance and resistance exercise help physically active postmenopausal women (including those with well‑controlled mild hypertension) improve heart and metabolic health, strength, body composition, and menopause symptoms.

Quick facts

Study typeInterventional
Ages46 Years to 65 Years
SexWomen only
Enrollment60 (estimated)
SponsorUniversidade da Coruña
Academic / other
Locations1 site (Oleiros, A Coruña)
StatusRecruiting
StartedMay 4, 2026
Main results expectedDecember 2028
Study endsDecember 2028
Registry record updatedJuly 7, 2026
Trial IDNCT07377383 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are physically active women at least one year post-menopause who are asymptomatic, have no major cardiometabolic or renal disease, and—if hypertensive—have well‑controlled grade 1 hypertension managed with a single medication.

Probably not a fit

Women with grade 2–3 hypertension, hypertension requiring multiple or interfering medications (e.g., beta‑blockers), current or prior hormone replacement therapy, symptomatic cardiovascular/metabolic/renal disease, or a hypertensive response to exercise are unlikely to benefit or are excluded.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional project enrolls physically active postmenopausal women to complete a 20-week supervised concurrent training program combining endurance and resistance exercise with different effort configurations across groups. The endurance component is experimentally controlled and resistance training set structures are varied to compare longitudinal neuromuscular, body composition, cardiometabolic, and perceptual adaptations and potential interference effects. Outcomes include blood pressure, lipids, glucose tolerance, vascular function, muscle strength, body composition, quality of life, mood state, and menopause-related symptoms. Training and all assessments are conducted on-site at the Faculty of Sport Sciences and Physical Education, Universidade da Coruña.

Why it matters

Potential benefit: If successful, the program could identify exercise combinations that improve blood pressure, metabolism, strength, body composition, and quality of life for postmenopausal women.

How similar studies have gone: Previous work from the same research group demonstrated benefits from varying resistance training configurations in postmenopausal women, while the broader literature on concurrent training shows mixed results regarding interference between endurance and resistance modalities.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* At least one year since the last menstrual period.
* Physically active, defined as engaging in 150-300 minutes of moderate physical activity per week or at least 75 minutes of vigorous activity per week.
* Three or fewer traditional cardiovascular risk factors.
* Asymptomatic and without cardiovascular (except controlled hypertension), metabolic, or renal diseases.
* In the case of hypertensive participants, well-controlled grade 1 hypertension managed with a single medication.

Exclusion Criteria:

* Diagnosis of grade 2 or grade 3 hypertension.
* Hypertension managed with more than one medication or with a drug that could interfere with cardiovascular responses to exercise (e.g., beta-blockers).
* Current or prior use of hormone replacement therapy.
* Hypertensive response to exercise.

Where it's running

  • Faculty of Sport Sciences and Physical Education - UDC
    Oleiros, A Coruña, Spain
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.