Cardiometabolic effects of different endurance-plus-resistance exercise prescriptions in postmenopausal women
Official title: Cardiometabolic Adaptations to Resistance and Endurance Exercise: Effects of Effort Configuration in Concurrent Training for Postmenopausal Women
Run by Universidade da Coruña · NCT07377383 · Data updated 2026-11-12
This 20-week program tests whether different ways of combining endurance and resistance exercise help physically active postmenopausal women (including those with well‑controlled mild hypertension) improve heart and metabolic health, strength, body composition, and menopause symptoms.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 46 Years to 65 Years |
| Sex | Women only |
| Enrollment | 60 (estimated) |
| Sponsor | Universidade da Coruña Academic / other |
| Locations | 1 site (Oleiros, A Coruña) |
| Status | Recruiting |
| Started | May 4, 2026 |
| Main results expected | December 2028 |
| Study ends | December 2028 |
| Registry record updated | July 7, 2026 |
| Trial ID | NCT07377383 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are physically active women at least one year post-menopause who are asymptomatic, have no major cardiometabolic or renal disease, and—if hypertensive—have well‑controlled grade 1 hypertension managed with a single medication.
✕Probably not a fit
Women with grade 2–3 hypertension, hypertension requiring multiple or interfering medications (e.g., beta‑blockers), current or prior hormone replacement therapy, symptomatic cardiovascular/metabolic/renal disease, or a hypertensive response to exercise are unlikely to benefit or are excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional project enrolls physically active postmenopausal women to complete a 20-week supervised concurrent training program combining endurance and resistance exercise with different effort configurations across groups. The endurance component is experimentally controlled and resistance training set structures are varied to compare longitudinal neuromuscular, body composition, cardiometabolic, and perceptual adaptations and potential interference effects. Outcomes include blood pressure, lipids, glucose tolerance, vascular function, muscle strength, body composition, quality of life, mood state, and menopause-related symptoms. Training and all assessments are conducted on-site at the Faculty of Sport Sciences and Physical Education, Universidade da Coruña.
Why it matters
Potential benefit: If successful, the program could identify exercise combinations that improve blood pressure, metabolism, strength, body composition, and quality of life for postmenopausal women.
How similar studies have gone: Previous work from the same research group demonstrated benefits from varying resistance training configurations in postmenopausal women, while the broader literature on concurrent training shows mixed results regarding interference between endurance and resistance modalities.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least one year since the last menstrual period. * Physically active, defined as engaging in 150-300 minutes of moderate physical activity per week or at least 75 minutes of vigorous activity per week. * Three or fewer traditional cardiovascular risk factors. * Asymptomatic and without cardiovascular (except controlled hypertension), metabolic, or renal diseases. * In the case of hypertensive participants, well-controlled grade 1 hypertension managed with a single medication. Exclusion Criteria: * Diagnosis of grade 2 or grade 3 hypertension. * Hypertension managed with more than one medication or with a drug that could interfere with cardiovascular responses to exercise (e.g., beta-blockers). * Current or prior use of hormone replacement therapy. * Hypertensive response to exercise.
Where it's running
-
Faculty of Sport Sciences and Physical Education - UDC
Oleiros, A Coruña, Spain Recruiting
Study contacts
- Principal investigator: Eliseo Iglesias-Soler, PhD — Universidade da Coruña
- Study coordinator: Eliseo Iglesias-Soler, PhD
- Email: eliseo.iglesias.soler@udc.es
- Phone: +3498167000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Using low-dose aspirin after preeclampsia to improve recovery
This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.
-
IMB-guided health education to boost medication taking and blood pressure control in adults with hypertension
This study tests a health-literacy program based on Information-Motivation-Behavioral Skills to help adults with hypertension who don’t take their medicines regularly to take them more consistently and better control their blood pressure.
-
Renal Nerve Stimulation to Help Blood Pressure in AF and HFpEF
This study tests whether stimulating the kidneys with a catheter can safely lower blood pressure in adults with atrial fibrillation and HFpEF who also have hypertension.
-
Hypertension: Does Education Help Patients Manage Blood Pressure Better?
This study tests whether structured patient education improves blood pressure control and self-management in adults with hypertension who speak Turkish.
-
High BMI and periodontitis in Thai adults under 60
This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.
-
Long-term GW906 treatment for people with essential hypertension
This trial tests whether long-term GW906 injections are safe and effective for adults with essential hypertension who completed an earlier GW906 study.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.