Cardiometabolic effects of different endurance-plus-resistance exercise prescriptions in postmenopausal women
Cardiometabolic Adaptations to Resistance and Endurance Exercise: Effects of Effort Configuration in Concurrent Training for Postmenopausal Women
This 20-week program tests whether different ways of combining endurance and resistance exercise help physically active postmenopausal women (including those with well‑controlled mild hypertension) improve heart and metabolic health, strength, body composition, and menopause symptoms.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 46 Years to 65 Years |
| Sex | Female |
| Sponsor | Universidade da Coruña Academic / other |
| Locations | 1 site (Oleiros, A Coruña) |
| Trial ID | NCT07377383 on ClinicalTrials.gov |
What this trial studies
This interventional project enrolls physically active postmenopausal women to complete a 20-week supervised concurrent training program combining endurance and resistance exercise with different effort configurations across groups. The endurance component is experimentally controlled and resistance training set structures are varied to compare longitudinal neuromuscular, body composition, cardiometabolic, and perceptual adaptations and potential interference effects. Outcomes include blood pressure, lipids, glucose tolerance, vascular function, muscle strength, body composition, quality of life, mood state, and menopause-related symptoms. Training and all assessments are conducted on-site at the Faculty of Sport Sciences and Physical Education, Universidade da Coruña.
Who should consider this trial
Good fit: Ideal candidates are physically active women at least one year post-menopause who are asymptomatic, have no major cardiometabolic or renal disease, and—if hypertensive—have well‑controlled grade 1 hypertension managed with a single medication.
Not a fit: Women with grade 2–3 hypertension, hypertension requiring multiple or interfering medications (e.g., beta‑blockers), current or prior hormone replacement therapy, symptomatic cardiovascular/metabolic/renal disease, or a hypertensive response to exercise are unlikely to benefit or are excluded.
Why it matters
Potential benefit: If successful, the program could identify exercise combinations that improve blood pressure, metabolism, strength, body composition, and quality of life for postmenopausal women.
How similar studies have performed: Previous work from the same research group demonstrated benefits from varying resistance training configurations in postmenopausal women, while the broader literature on concurrent training shows mixed results regarding interference between endurance and resistance modalities.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least one year since the last menstrual period. * Physically active, defined as engaging in 150-300 minutes of moderate physical activity per week or at least 75 minutes of vigorous activity per week. * Three or fewer traditional cardiovascular risk factors. * Asymptomatic and without cardiovascular (except controlled hypertension), metabolic, or renal diseases. * In the case of hypertensive participants, well-controlled grade 1 hypertension managed with a single medication. Exclusion Criteria: * Diagnosis of grade 2 or grade 3 hypertension. * Hypertension managed with more than one medication or with a drug that could interfere with cardiovascular responses to exercise (e.g., beta-blockers). * Current or prior use of hormone replacement therapy. * Hypertensive response to exercise.
Where this trial is running
Oleiros, A Coruña
- Faculty of Sport Sciences and Physical Education - UDC — Oleiros, A Coruña, Spain (Recruiting)
Study contacts
- Principal investigator: Eliseo Iglesias-Soler, PhD — Universidade da Coruña
- Study coordinator: Eliseo Iglesias-Soler, PhD
- Email: eliseo.iglesias.soler@udc.es
- Phone: +3498167000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.