Cardiac Function and Anesthesia Depth During Heart Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized, parallel-group study, adults undergoing on-pump cardiac surgery are assigned to either a BIS-guided anesthesia depth of 45-55 or 30-35. Cardiac function is measured with transthoracic echocardiography including strain imaging and myocardial work, while invasive monitoring collects hemodynamic data. The primary goal is to compare changes in left ventricular global longitudinal strain between two intraoperative time points after induction and after separation from bypass. Outcome assessors are blinded to treatment allocation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years or older, irrespective of sex.
* Scheduled to undergo elective cardiac surgery involving cardiopulmonary bypass (on-pump surgery).
* Anticipated adequate acoustic window for transthoracic echocardiography.
* Provision of written informed consent.

Exclusion Criteria:

* \- Emergency or unscheduled cardiac surgery.
* Cardiac surgery without cardiopulmonary bypass (off-pump surgery).
* Refusal or inability to provide written informed consent.

Where it's running

• AHEPA University General Hospital of Thessaloniki
  Thessaloniki, Greece Recruiting

Study contacts

• Principal investigator: Christos Mantzios, Cardiology Resident, MD, MSc — 1st Department of Cardiology, School of Medicine, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece
• Study coordinator: Christos Mantzios, Cardiology Resident, MD, MSc
• Email: chrismantzios1994@gmail.com
• Phone: +306983282188

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.