Cannabidiol suppositories for sexual pain
The Use of Cannabidiol Suppositories for Sexual Pain: A Randomised Controlled Study
This project will test whether cannabidiol suppositories can reduce sexual pain and improve sexual function and well-being for adults who experience pain during intercourse or masturbation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | London Metropolitan University Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT07271030 on ClinicalTrials.gov |
What this trial studies
Adults who report sexual pain are randomized to one of four groups: three cannabidiol suppository dose groups (about 30 mg, 50 mg, and 100 mg) or a care-as-usual control. The suppository intervention is used over one month with a planned follow-up visit at 12 weeks to measure pain, sexual function, quality of life, and well-being. The trial combines quantitative outcomes with qualitative feedback gathered via approximately eight open-ended questions. Participants must have prior cannabidiol use without allergy and meet mild screening thresholds for depression and anxiety to minimize confounding comorbidities.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 or older who are currently experiencing sexual pain, have previously used cannabidiol without allergic reaction, have tried intercourse in the past month, and screen in the mild range on PHQ-9 and GAD-7.
Not a fit: People with a history of allergic reaction to cannabidiol, moderate-to-severe depression or anxiety, co-occurring clinical difficulties, those under 18, or those not sexually active recently are unlikely to be eligible or benefit from this intervention.
Why it matters
Potential benefit: If successful, this could provide a non-intoxicating, locally delivered option to lessen sexual pain and improve sexual function, quality of life, and overall well-being.
How similar studies have performed: Two small prior studies of cannabidiol suppositories have suggested pain-relieving effects for sexual pain, but the evidence remains limited and preliminary.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Has previously used cannabidiol in any capacity and has not experienced any allergic reaction * Is experiencing sexual pain * There will be an absence of co occurring difficulties * Has attempted sexual intercourse in the last month * Age 18 years or older * Read and write English * Patient Health Questionnaire 9 screening score range between 0-9 mild * General Anxiety Disorder 7 screening score range between 0-9 mild * There are no restrictions on sex, gender, sexuality, or disability Exclusion Criteria: Has experienced an allergic reaction to cannabidiol in any capacity * Has not attempted sexual intercourse in the last month * Has co occurring difficulties * Aged below 18 years old * Are not experiencing sexual pain * Patient Health Questionnaire 9 screening score range between moderate to severe - 10-27 * General Anxiety Disorder 7 screening score range between 10- 21.
Where this trial is running
London
- School of Social Sciences and Professions — London, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Samantha Banbury — London Metropolitan University
- Study coordinator: Anna Kamyk
- Email: rpo@londonmet.ac.uk
- Phone: 02074230000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.