Can pre-surgery lean (fat-free) mass predict weight loss after Roux-en-Y gastric bypass?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational cohort (with retrospective data included) of adults undergoing or previously treated with Roux-en-Y gastric bypass at Geneva University Hospitals. Investigators will measure preoperative body composition (BIA and DXA), handgrip strength, resting energy expenditure, eating and activity questionnaires, clinical labs, and routinely collected anthropometrics. These measures and questionnaires will be repeated at scheduled follow-ups up to two years after surgery, and blood/tissue samples will be banked. The primary analysis will correlate preoperative fat-free mass with weight change over the two-year postoperative period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients ≥ 18 years AND
* Meeting inclusion criteria for RYGB (www.smob.ch): BMI ≥35 kg/m2, failure of weight-reducing programs over 2 years (for patients with a BMI ≥50 kg/m2, 1 year), understanding of the necessity to change the lifestyle and eating habits post-operatively, signed consent for lifelong post-operative follow-up in a recognized bariatric center AND
* Scheduled RYGB at the HUG OR previous RYGB at the HUG with a present follow-up in Clinical Nutrition and dietetics at the HUG AND
* Understanding French

Exclusion Criteria:

* Inability or refusal to give consent.
* Planification for another type of bariatric surgery than RYGB
* Contra-indications to bariatric surgery as stated under www.smob.ch: insufficient nutritional knowledge in nutrition to lose weight, pregnancy, kidney failure (Creatinine ≥ 300 umol/l without dialysis, Crohn's disease, active cancer or remission \< 2 years, active psychiatric disease, substance abuse (alcohol, cannabis, opioids), absence of compliance, lack of understanding of the requirements and necessary lifestyle changes reported by physician or dietician.

Where it's running

• Geneva University Hospitals
  Geneva, Canton of Geneva, Switzerland Recruiting

Study contacts

• Study coordinator: Laurence Genton, MD
• Email: laurence.genton@hug.ch
• Phone: 0041 79 553 34 84

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.