Cabergoline plus coasting to reduce ovarian hyperstimulation syndrome
Official title: Clinical Study to Evaluate Efficacy of Cabergoline to Coasting in Reducing the Incidence of Ovarian Hyperstimulation Syndrome
Run by Tanta University · NCT07043322 · Data updated 2026-11-12
This test checks whether adding cabergoline to coasting lowers the chance of ovarian hyperstimulation syndrome in women at high risk during gonadotropin ovarian stimulation.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 20 Years to 35 Years |
| Sex | Women only |
| Enrollment | 150 (estimated) |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Damietta, New Damietta) |
| Status | Recruiting |
| Started | June 30, 2025 |
| Main results expected | October 20, 2026 |
| Study ends | November 20, 2026 |
| Registry record updated | March 13, 2026 |
| Trial ID | NCT07043322 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 18–38 with BMI under 30 using a long luteal gonadotropin stimulation protocol who meet high-risk criteria for OHSS (more than 20 follicles >12 mm and/or estradiol >3000 pg/ml when the leading follicle is >15 mm) and have Day 2 FSH <10 mIU/L and E2 <50 pg/ml.
✕Probably not a fit
Patients with uncontrolled chronic diseases (severe liver, kidney, cardiac disease, uncontrolled hypertension or diabetes), known allergy to cabergoline, BMI ≥30, or outside the 18–38 age range are unlikely to qualify or benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This Phase 2 interventional study enrolls women at high risk for OHSS who are undergoing controlled ovarian stimulation with a long luteal protocol. Participants will undergo standard coasting and some will also receive cabergoline, with clinicians monitoring follicle growth, estradiol levels, and clinical signs of OHSS. The main outcome is the incidence and severity of OHSS, with safety and adverse events tracked throughout stimulation and the peri-trigger period. The protocol excludes patients with major uncontrolled medical conditions or known allergy to cabergoline.
Why it matters
Potential benefit: If successful, this approach could reduce the risk and severity of OHSS, lowering complications and the need for hospitalization during fertility treatment.
How similar studies have gone: Previous studies have shown cabergoline can modestly reduce OHSS risk and coasting is an established prevention method, so combining them has some supportive but not definitive evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18-38 years * Body mass index (calculated as weight in kilograms divided by the square of height in meters) \< 30 kg/m2. * A long luteal protocol is used for ovarian stimulation. * Day 2 FSH \<10 mIU/L and E2\< 50 pg/ml * High risk of OHSS, defined as having more than 20 follicles \>12 mm in diameter and/or E2 levels \> 3000 pg/ml when the size of the leading follicle is \> 15 mm Exclusion Criteria: The presence of chronic medical diseases, including liver cell failure, renal failure, uncontrolled hypertension, uncontrolled diabetes mellitus, or class 3 or 4 function heart disease in the New York heart association classification. Allergy to Cabergoline.
Where it's running
-
Mostafa Bahaa
Damietta, New Damietta, Egypt Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.