Burst stimulation with pulmonary vein and superior vena cava isolation for paroxysmal atrial fibrillation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients with paroxysmal atrial fibrillation scheduled for their first radiofrequency catheter ablation will undergo pulmonary vein isolation plus superior vena cava isolation with intra‑procedural burst electrical stimulation to provoke and target arrhythmia triggers. The protocol enrolls adults aged 18–80 without significant organic heart disease or prior atrial ablation and requires stopping antiarrhythmic drugs when possible. Participants will be followed for at least 12 months for arrhythmia recurrence and safety outcomes. The main outcomes include AF recurrence rates and procedure‑related complications over the follow‑up period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ages 18 to 80 years old;
* Documented diagnosis of paroxysmal atrial fibrillation (self-terminating and lasting \< 7 days);
* Patients scheduled for initial radiofrequency catheter ablation (RFCA) treatment;
* Able to sign the informed consent form and comply with a minimum of 12 months of follow-up.

Exclusion Criteria:

* Presence of organic heart disease (e.g., rheumatic heart disease, severe valvular stenosis or regurgitation, post-valve replacement, or dilated cardiomyopathy);
* Concomitant atrial tachyarrhythmia requiring radiofrequency ablation (including typical atrial flutter and atrial tachycardia);
* Prior history of catheter ablation for any atrial tachyarrhythmia (including atrial fibrillation, atrial flutter, or atrial tachycardia);
* Concomitant hyperthyroidism, active malignant tumor, or other serious illness with a life expectancy of \<1 year;
* Contraindications to anticoagulation;
* Inability to discontinue antiarrhythmic drugs for reasons other than atrial fibrillation;
* Pregnant or breastfeeding women.

Where it's running

• Zhongnan Hospital of Wuhan University
  Wuhan, Hubei, China Recruiting
• Xiangyang Central Hospital
  Xiangyang, Hubei, China Recruiting
• Yichang Central People's Hospital
  Yichang, Hubei, China Recruiting

Study contacts

• Study coordinator: Zhibing Lu
• Email: luzhibing222@163.com
• Phone: 027-67812783

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.