Bupivacaine versus ropivacaine for bleeding control and pain in lower wisdom tooth removal
Comparative Experimental Study Between Bupivacaine and Ropivacaine Regarding Efficacy in Third Molar Removal Surgery Under General Anesthesia
This project will test whether bupivacaine or ropivacaine gives better bleeding control, steadier vital signs, and less pain after lower wisdom tooth removal under general anesthesia in adults.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Federal University of Rio Grande do Sul Academic / other |
| Locations | 1 site (Porto Alegre, Rio Grande do Sul) |
| Trial ID | NCT07108465 on ClinicalTrials.gov |
What this trial studies
This early phase 1, interventional split-mouth comparison gives each participant one side treated with bupivacaine 0.5% and the other with ropivacaine 0.75% during lower third molar extraction under general anesthesia. Investigators will record intraoperative hemostasis and changes in vital signs and ask participants to complete a Visual Analog Scale for postoperative pain. The design enrolls healthy adults (ASA I–II) with similarly positioned impacted or semi-impacted lower third molars on both sides. The study is conducted at Hospital de Clínicas de Porto Alegre with a single surgical session and postoperative follow-up.
Who should consider this trial
Good fit: Adults aged 18–60 with ASA physical status I or II and impacted or semi-impacted lower third molars positioned similarly on both sides (per Pell and Gregory) are ideal candidates.
Not a fit: Patients who are eligible for local anesthesia, who require additional procedures in the same session, who are ASA III or higher, or who fall outside the 18–60 age range may not receive benefit from this comparison.
Why it matters
Potential benefit: If successful, the trial could identify the anesthetic that produces less postoperative pain and better bleeding control with fewer vital sign disturbances, improving recovery after lower wisdom tooth extraction.
How similar studies have performed: Previous comparisons of bupivacaine and ropivacaine in regional and dental anesthesia generally show comparable pain control with ropivacaine having a more favorable cardiotoxicity profile, but split-mouth comparisons under general anesthesia for third molar removal are less common.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 to 60 * Patients ASA Physical Status Classification I and II * Patients with impacted or semi-impacted lower third molars with similar positioning on both sides according to the Pell and Gregory classification Exclusion Criteria: * Patients who can have surgery under local anesthesia * Patients where more procedures are required in the same surgical session
Where this trial is running
Porto Alegre, Rio Grande do Sul
- Hospital de Clínicas de Porto Alegre — Porto Alegre, Rio Grande do Sul, Brazil (Recruiting)
Study contacts
- Study coordinator: Henrique T Oliveira
- Email: htedesco99@gmail.com
- Phone: 55 51999601939
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.