Bupivacaine versus ropivacaine for bleeding control and pain in lower wisdom tooth removal
Official title: Comparative Experimental Study Between Bupivacaine and Ropivacaine Regarding Efficacy in Third Molar Removal Surgery Under General Anesthesia
Run by Federal University of Rio Grande do Sul · NCT07108465 · Data updated 2026-11-12
This project will test whether bupivacaine or ropivacaine gives better bleeding control, steadier vital signs, and less pain after lower wisdom tooth removal under general anesthesia in adults.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | Federal University of Rio Grande do Sul Academic / other |
| Locations | 1 site (Porto Alegre, Rio Grande do Sul) |
| Status | Recruiting |
| Started | July 1, 2025 |
| Main results expected | September 30, 2025 |
| Study ends | December 31, 2026 |
| Registry record updated | May 1, 2026 |
| Trial ID | NCT07108465 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–60 with ASA physical status I or II and impacted or semi-impacted lower third molars positioned similarly on both sides (per Pell and Gregory) are ideal candidates.
✕Probably not a fit
Patients who are eligible for local anesthesia, who require additional procedures in the same session, who are ASA III or higher, or who fall outside the 18–60 age range may not receive benefit from this comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This early phase 1, interventional split-mouth comparison gives each participant one side treated with bupivacaine 0.5% and the other with ropivacaine 0.75% during lower third molar extraction under general anesthesia. Investigators will record intraoperative hemostasis and changes in vital signs and ask participants to complete a Visual Analog Scale for postoperative pain. The design enrolls healthy adults (ASA I–II) with similarly positioned impacted or semi-impacted lower third molars on both sides. The study is conducted at Hospital de Clínicas de Porto Alegre with a single surgical session and postoperative follow-up.
Why it matters
Potential benefit: If successful, the trial could identify the anesthetic that produces less postoperative pain and better bleeding control with fewer vital sign disturbances, improving recovery after lower wisdom tooth extraction.
How similar studies have gone: Previous comparisons of bupivacaine and ropivacaine in regional and dental anesthesia generally show comparable pain control with ropivacaine having a more favorable cardiotoxicity profile, but split-mouth comparisons under general anesthesia for third molar removal are less common.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 to 60 * Patients ASA Physical Status Classification I and II * Patients with impacted or semi-impacted lower third molars with similar positioning on both sides according to the Pell and Gregory classification Exclusion Criteria: * Patients who can have surgery under local anesthesia * Patients where more procedures are required in the same surgical session
Where it's running
-
Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil Recruiting
Study contacts
- Study coordinator: Henrique T Oliveira
- Email: htedesco99@gmail.com
- Phone: 55 51999601939
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Can virtual reality with hypnotic scripts ease dental anxiety during wisdom tooth removal?
This trial tests whether using virtual reality with hypnotic scripts can lower anxiety and pain for adults undergoing wisdom tooth extraction compared with standard local anesthesia alone.
-
PRF plus corticosteroids vs PRF alone vs standard care for impacted lower wisdom teeth
This study tests whether using platelet-rich fibrin, with or without a corticosteroid, can reduce pain and swelling after removing an impacted lower third molar.
-
Autologous Tooth Graft vs. Bovine Xenograft for Healing After Lower Wisdom Tooth Extraction
This study tests whether using tooth-derived grafts from the extracted tooth or bovine grafts improves healing of periodontal defects after removing impacted lower wisdom teeth, compared to natural blood clot healing.
-
Testing a new gel for pain relief after wisdom tooth extraction
This study is testing a new gel for pain relief after wisdom tooth removal to see if it works better than a placebo and how well it's absorbed in the body.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.