Bridge to surgery for right-sided obstructive colon cancer
Obstructive Colon Cancer, a Bridge to Surgery in Right Sided Obstructive Colon Cancer
This study is testing a new way to help patients with right-sided obstructive colon cancer by using a temporary solution to relieve their blockage before they have surgery, to see if it can lower the risks of complications after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 110 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Amphia Hospital Academic / other |
| Locations | 1 site (Breda, North Brabant) |
| Trial ID | NCT06338332 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the feasibility of a bridge to surgery (BTS) protocol for patients with right-sided obstructive colon cancer. The BTS approach involves either creating an ileostomy or placing a stent to relieve obstruction, followed by definitive surgical treatment at a later stage. The study focuses on reducing postoperative mortality and morbidity rates associated with emergency resection in these patients. By analyzing outcomes from participating hospitals, the study seeks to provide insights into the effectiveness of this management strategy.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older presenting with symptoms of obstruction due to suspected or confirmed colonic cancer.
Not a fit: Patients with benign causes of obstruction, advanced disease requiring palliative care, or rectal cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly lower the risks of complications and mortality for patients with right-sided obstructive colon cancer.
How similar studies have performed: While the bridge to surgery approach is gaining traction, this specific protocol's effectiveness in right-sided obstructive colon cancer is still being evaluated and may be considered novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients age is 18 years or older * Patients presenting with symptoms of obstruction (including cecum, ascending colon, hepatic flexure, transverse colon, splenic flexure, descending colon, sigmoid colon) caused by (high suspicion or histologically proven) colonic cancer. * Patient presenting with symptoms of partial obstruction (abdominal pain, nausea, vomiting, diarrhoea) confirmed by the presence of a dilated colon or ileum with a computed tomography (CT-scan). * Treatment with curative intent. Exclusion Criteria: * Obstruction of the colon pathologically caused by benign disease. * Obstruction of the colon caused by an extra-colonic malignancy. * Suspicion of emergency complications caused by peritonitis due to perforation (tumour or blow out) or sepsis. * Patients with advanced disease who will undergo a palliative trajectory. * Rectal cancer
Where this trial is running
Breda, North Brabant
- Amphia Hospital — Breda, North Brabant, Netherlands (Recruiting)
Study contacts
- Principal investigator: Jennifer Schreinemakers, MD, PhD — Amphia Hospital Breda, The Netherlands
- Study coordinator: Elze Lockhorst, Drs.
- Email: elockhorst@amphia.nl
- Phone: +31613723827
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.