Breathing and muscle strength in people with COPD or PRISm

Comparison of Respiratory and Peripheral Muscle Strength, Exercise Capacity, and Muscle Oxygenation in Individuals With COPD and PRISM

This project will test breathing muscle strength, limb muscle strength, and oxygen levels in people over 40 who have COPD, PRISm, or no lung disease.

Quick facts

• Study type: Observational
• Enrollment: 60 (estimated)
• Ages: 40 Years and up
• Sex: All
• Sponsor: Karabuk University (Academic / other)
• Locations: 1 site (Karabük)
• Trial ID: NCT07249567 on ClinicalTrials.gov

What this trial studies

This observational study compares respiratory muscle strength, peripheral muscle strength, and oxygenation in adults over 40 with COPD, adults with PRISm, and healthy control participants. Participants are grouped by spirometry pattern and clinical stability and will undergo standardized measurements of lung function, muscle strength, and oxygen saturation. The collected data will be compared across groups to identify functional differences and patterns. Findings aim to clarify whether PRISm shows impairments similar to COPD and to inform monitoring and rehabilitation approaches.

Who should consider this trial

Good fit: Adults older than 40 who volunteer and either have a clinician diagnosis of COPD and are clinically stable, have PRISm, or are healthy without chronic disease are appropriate candidates.

Not a fit: People with severe orthopedic, neurological, or cardiac disease, comorbid lung diseases, those in COPD exacerbation or on unstable medications, and individuals under 40 are unlikely to benefit from participation.

Why it matters

Potential benefit: If successful, the results could help clinicians recognize functional deficits in PRISm and tailor monitoring or rehabilitation earlier to reduce risk of worsening or exacerbations.

How similar studies have performed: Direct comparisons of respiratory and peripheral muscle strength and oxygenation between PRISm, COPD, and healthy individuals are scarce, so this comparison is relatively novel.

Eligibility criteria

Inclusion Criteria:

For the COPD group:

* Being \>40 years old,
* Being diagnosed with COPD,
* Being clinically stable,
* Volunteering to participate in the study.

For the PRISm group:

* Being \>40 years old,
* Being diagnosed with PRISm,
* Volunteering to participate in the study.

For the healthy control group:

* Being \>40 years old,
* Volunteering to participate in the study.

Exclusion Criteria:

For the COPD group:

* Having severe orthopedic, neurological, or cardiac diseases,
* Being in a COPD exacerbation,
* Having a comorbid lung disease,
* Being on clinically unstable medication,
* Voluntarily not participating in the study.

For the PRISm group:

* Being diagnosed with COPD,
* Having severe orthopedic, neurological, or cardiac diseases,
* Having a comorbid lung disease,
* Voluntarily not participating in the study.

For the healthy control group:

* Having a known chronic disease,
* Voluntarily not participating in the study.

Where this trial is running

Karabük

• Karabuk University, Physiotherapy and Rehabilitation Application and Research Center — Karabük, Turkey (Türkiye) (Recruiting)

Study contacts

• Principal investigator: Musa Güneş, PhD — Karabuk University
• Study coordinator: Musa Güneş, PhD

Conditions COPD