Breath testing for gastric cancer screening
Official title: Screening of Gastric Cancer Via Breath Volatile Organic Compounds by Hybrid Sensing Approach
Run by University of Latvia · NCT04022109 · Data updated 2026-11-12
This study is testing if breath tests can help find gastric cancer and related conditions in people who have cancer, precancerous lesions, or are at average risk.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 5000 (estimated) |
| Sponsor | University of Latvia Academic / other |
| Locations | 5 sites (São Paulo and 4 other locations) |
| Status | Recruiting |
| Started | November 1, 2019 |
| Main results expected | December 2022 |
| Study ends | December 2026 |
| Registry record updated | July 26, 2021 |
| Trial ID | NCT04022109 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients with verified gastric cancer, those undergoing upper endoscopy, and average-risk individuals aged 40-64 without alarm symptoms.
✕Probably not a fit
Patients with other active cancers or those unable to cooperate due to ventilation problems may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of volatile organic compound (VOC) testing in screening for gastric cancer and related conditions. It will enroll patients with established gastric cancer, precancerous lesions, and individuals from the general population at average risk. The study will utilize gas chromatography coupled with mass spectroscopy and sensor technology to analyze breath samples for VOCs. Additionally, it will investigate the influence of lifestyle factors and microbiota on VOC composition.
Why it matters
Potential benefit: If successful, this study could provide a non-invasive method for early detection of gastric cancer, potentially improving patient outcomes.
How similar studies have gone: Other studies have explored breath testing for cancer detection, showing promise, but this specific approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with verified gastric cancer (Group 1 \& 2) * Patients undergoing or having undergone upper endoscopy according to clinical indications (Group 3 \& 5) * Average-risk population group aged 40-64 at inclusion without alarm symptoms (Group 4) * Motivation to participate in the study * Physical status allowing volatile marker sampling and other procedures within the protocol * Signed consent Exclusion Criteria: * Known other active cancer * Ventilation problems, airway obstruction * Unwillingness or inability to co-operate
Where it's running
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A.C.Camargo Cancer Center
São Paulo, Brazil Recruiting -
Institute of Clinical and Preventive Medicine, University of Latvia
Riga, Latvia Recruiting -
National Cancer Institute of Ukraine
Kiev, Ukraine Recruiting -
Pontificia Universidad Catolica de Chile
Santiago, Chile Not yet recruiting -
Centro Javeriano de Oncología, San Ignacio University Hospital
Bogotá, Colombia Not yet recruiting
Study contacts
- Principal investigator: Hossam Haick, PhD — TECHNION, Israel Institute for Technology
- Study coordinator: Marcis Leja, MD, PhD
- Email: marcis.leja@lu.lv
- Phone: +37129497500
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Monitoring patients with precursors to gastric cancer
This study is testing the best ways to monitor people over 45 with early signs of stomach cancer to help keep them safe and healthy.
-
Mobile capsule gastroscopy for detecting stomach problems in older and high-risk people
This project will test if an AI-assisted swallowable camera (mobile capsule gastroscopy) can find stomach diseases in older adults and people at higher risk.
-
Predicting gastric cancer risk in patients with intestinal metaplasia and atrophic gastritis
This study is trying to find out which factors can help predict the risk of gastric cancer in patients who have intestinal metaplasia and atrophic gastritis.
-
Observational study on gastric precancerous conditions
This study looks at people who are at higher risk for stomach cancer to see how conditions like atrophic gastritis and intestinal metaplasia develop over time.
-
Monitoring patients with precancerous stomach lesions
This study is trying to find out how to better monitor people with precancerous stomach lesions to see who is at risk of developing gastric cancer and when they should come back for check-ups.
-
Preventing gastric cancer mortality through H. Pylori eradication and pepsinogen testing
This study is testing if treating Helicobacter pylori infections and monitoring stomach health can help lower the risk of gastric cancer in middle-aged people living in high-risk areas.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.