Breath test for detecting gastrointestinal cancers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to validate the use of breath analysis for detecting volatile organic compounds (VOCs) associated with gastrointestinal cancers, including oesophageal, gastric, pancreatic, liver, and colorectal cancers. By recruiting at least 8,000 individuals with suspected cancer from 40 centers, the study will assess the effectiveness of a simple breath test in identifying these cancers early. The research will also explore the optimal implementation strategy for this test in primary care settings and evaluate its cost-effectiveness. The goal is to improve early diagnosis and ultimately enhance survival rates for patients with gastrointestinal cancers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged ≥ 18 years old.
* Participants with non-specific symptoms referred from primary care along upper and lower gastrointestinal cancer pathways for the reference test (upper/lower gastrointestinal endoscopy, CT/MRI/ultrasound ± histological/cytological confirmation).
* Willing and able to provide informed written consent to take part in study.

Exclusion Criteria:

* Previous oesophageal, gastric, liver, pancreatic or colonic resection
* History of another cancer within three years
* Co-morbidities preventing breath collection
* Pregnant participants
* Unable or unwilling to provide informed written consent.

Where it's running

• Imperial NHS Trust
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Michael Fadel, BSc MBBS MRCS
• Email: m.fadel@imperial.ac.uk
• Phone: +44 (0)20 7594 3396

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.