Brain PET scan with [18F]NIDF to see tau protein in Alzheimer’s and other tau-related diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational imaging project uses the radioactive tracer [18F]NIDF injected before PET scanning to visualize abnormal tau neurofibrillary tangles in living human brains. The tracer is a 2-arene-azaindole-based compound designed for stronger tau binding and reduced off-target signal compared with existing tau PET agents. Adult participants (ages 18–90), including healthy volunteers and people with probable Alzheimer’s or other dementias, will be enrolled and undergo tracer injection and PET imaging at participating hospitals. The primary focus is on imaging safety and how well the tracer highlights tau pathology for diagnostic use.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Between 18 and 90 years old;
2. No gender limitation;
3. Clinical diagnositic rerults supported the diagnosis of neurodegeneration, and there was no evidence of other neurological diseases;
4. Healthy participants or patients with probable Alzheimer's disease or with dementia due to other causes;
5. Informed consent signed in person by the subject or his legal guardian or caregiver.

Exclusion Criteria:

1. Has allergy to \[18F\]NIDF or any of its excipients;
2. Incapable of providing written informed consent or lacking a legally authorized representative (LAR) to provide informed consent ;
3. Unwilling or unable to undergo PET scans tracer injections;
4. Any condition that, in the Investigator's opinion, could increase the risk to the participant, limit the participant's ability to tolerate the research procedures, or interfere with the collection/analysis of the data (e.g., renal or liver failure, advanced cancer);
5. Received an experimental drug or device within 1 month (whose efficacy or safety is unclear);
6. Have other serious neurological disorders, or gastrointestinal, cardiovascular, liver, kidney, blood system, tumor, endocrine, respiratory, immune deficiency, and other serious diseases;
7. Women who are currently pregnant or breastfeeding.

Where it's running

• The First Affiliated Hospital of University of Science and Technology of China
  Hefei, Anhui, China Recruiting
• The Affiliated Hospital of Qingdao University
  Qingdao, Shandong, China Recruiting
• Tianjin Medical University General Hospital
  Tianjin, Tianjin Municipality, China Recruiting

Study contacts

• Study coordinator: Ying Wang, MD
• Email: macrossplusvoices@163.com
• Phone: +8618702292537

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.