Brain network changes in adults with anemia measured by fNIRS
Construction of Abnormal Projection Regions of Cognitive Neural Networks in Patients With Anemia Using Functional Near-Infrared Spectroscopy (fNIRS)
Institute of Hematology & Blood Diseases Hospital, China · NCT07578675
This project will use functional near-infrared spectroscopy (fNIRS) to see if brain network connections are altered in adults aged 18–65 who have anemia.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 323 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Institute of Hematology & Blood Diseases Hospital, China (other) |
| Locations | 1 site (Tianjin, Tianjin Municipality) |
| Trial ID | NCT07578675 on ClinicalTrials.gov |
What this trial studies
The study will use fNIRS to record fluctuations in oxygenated and deoxygenated hemoglobin as a proxy for neural network activity in anemic patients. Researchers will map connectivity changes and highlight affected regions using heatmaps and arc-based visualizations. Participants are adults (18–65) with a diagnosis of anemia who are on their first hospitalization and able to give informed consent, with exclusions for psychiatric illness and severe brain disease. The goal is to link network abnormalities to cognitive symptoms to support earlier detection and targeted interventions.
Who should consider this trial
Good fit: Adults aged 18–65 with a clinical diagnosis of anemia who are hospitalized for the first time and can provide written informed consent are the intended participants.
Not a fit: People with a history of psychiatric illness, severe brain disease, or other investigator-determined exclusion reasons (and those outside the 18–65 age range or not hospitalized for the first time) are unlikely to benefit from this specific protocol.
Why it matters
Potential benefit: If successful, this work could enable earlier detection of cognitive impairment in people with anemia and help guide more personalized treatment to improve daily function and quality of life.
How similar studies have performed: fNIRS has been used successfully to study brain network function in other cognitive disorders, but applying detailed connectivity heatmaps to anemia-specific cognitive changes is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of anemia * First hospitalization * Male or female, aged 18-65 years * Willing and able to comply with the requirements for this study and written informed consent Exclusion Criteria: * History of psychiatric illness * History of severe brain disease * Subjects that the investigator believes have other reasons that make them unsuitable for inclusion in this study
Where this trial is running
Tianjin, Tianjin Municipality
- Regenerative Medicine Center — Tianjin, Tianjin Municipality, China (RECRUITING)
Study contacts
- Study coordinator: ZheXiang Kuang, MSN
- Email: kuangzhexiang@ihcams.ac.cn
- Phone: 13920361752
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Aplastic Anemia, Myelodysplastic Syndromes, Autoimmune Hemolytic Anemia, Functional Near-Infrared Spectroscopy