Clinical trial Recruiting at 1 site Observational Ages 18 to 65

Brain network changes in adults with anemia measured by fNIRS

Official title: Construction of Abnormal Projection Regions of Cognitive Neural Networks in Patients With Anemia Using Functional Near-Infrared Spectroscopy (fNIRS)

Run by Institute of Hematology & Blood Diseases Hospital, China · NCT07578675 · Data updated 2026-11-12

This project will use functional near-infrared spectroscopy (fNIRS) to see if brain network connections are altered in adults aged 18–65 who have anemia.

Quick facts

Study typeObservational
Ages18 Years to 65 Years
SexAll
Enrollment323 (estimated)
SponsorInstitute of Hematology & Blood Diseases Hospital, China
Academic / other
Locations1 site (Tianjin, Tianjin Municipality)
StatusRecruiting
StartedOctober 11, 2025
Main results expectedMarch 31, 2028
Study endsDecember 31, 2028
Registry record updatedSeptember 18, 2026
Trial IDNCT07578675 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–65 with a clinical diagnosis of anemia who are hospitalized for the first time and can provide written informed consent are the intended participants.

Probably not a fit

People with a history of psychiatric illness, severe brain disease, or other investigator-determined exclusion reasons (and those outside the 18–65 age range or not hospitalized for the first time) are unlikely to benefit from this specific protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study will use fNIRS to record fluctuations in oxygenated and deoxygenated hemoglobin as a proxy for neural network activity in anemic patients. Researchers will map connectivity changes and highlight affected regions using heatmaps and arc-based visualizations. Participants are adults (18–65) with a diagnosis of anemia who are on their first hospitalization and able to give informed consent, with exclusions for psychiatric illness and severe brain disease. The goal is to link network abnormalities to cognitive symptoms to support earlier detection and targeted interventions.

Why it matters

Potential benefit: If successful, this work could enable earlier detection of cognitive impairment in people with anemia and help guide more personalized treatment to improve daily function and quality of life.

How similar studies have gone: fNIRS has been used successfully to study brain network function in other cognitive disorders, but applying detailed connectivity heatmaps to anemia-specific cognitive changes is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosis of anemia
* First hospitalization
* Male or female, aged 18-65 years
* Willing and able to comply with the requirements for this study and written informed consent

Exclusion Criteria:

* History of psychiatric illness
* History of severe brain disease
* Subjects that the investigator believes have other reasons that make them unsuitable for inclusion in this study

Where it's running

  • Regenerative Medicine Center
    Tianjin, Tianjin Municipality, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.