Brain imaging to study the effects of methylphenidate in adults with ADHD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to identify neuroimaging biomarkers that can predict how patients with ADHD respond to methylphenidate treatment. It employs a double-blind crossover design where participants will receive both methylphenidate and a placebo, with their brain activity measured using functional MRI and brain chemistry assessed through magnetic resonance spectroscopy. The goal is to understand the neural changes associated with ADHD symptoms and treatment response, which could inform future pharmacological developments for the disorder.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* right handed

Exclusion Criteria:

* pregnant or breast feeding
* past or current neurological disorder
* non-ADHD cause of cognitive impairment
* uncontrolled medical disorder
* head trauma with loss of consciousness in the last year or any evidence of functional impairment due to and persisting after head trauma
* having an adverse reaction to methylphenidate, or other stimulant medication
* having a contraindication to MRI
* current smoking

Where it's running

• Johns Hopkins School of Medicine
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Kristin L Bigos, PhD — Johns Hopkins School of Medicine
• Study coordinator: Kristin L Bigos, PhD
• Email: kbigos1@jhu.edu
• Phone: 410-614-0453

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.