Brain connectivity changes in glioma patients during treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study involving adults with diffuse gliomas (WHO grades 2-4) who undergo repeated functional MRI and neurocognitive assessments as part of their care. The goal is to map how key brain regions and their white matter connections reorganize during treatment, shedding light on neuroplasticity in the context of glioma therapy. Imaging and cognitive data will be analyzed over the course of treatment to identify patterns of change and potential predictors of adaptation. No experimental interventions are described; the study relies on standard imaging and assessments available to participants. Results may inform understanding of brain resilience and guide future patient management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with diffuse gliomas (WHO grade 2-4).
* Age \>18 years and \<65 years.
* Written participant information and informed consent provided and signed.
* Signed informed consent for functional magnetic resonance imaging (fMRI).

Exclusion Criteria:

* Age \<18 years or \>65 years.
* Pregnancy.
* Contraindications to MRI, including but not limited to:

  * Active medical implants (e.g., pain pump, defibrillator, cardiac pacemaker),
  * Orthodontic braces,
  * Metallic tattoos,
  * Non-removable piercings,
  * Known metallic foreign bodies,
  * Claustrophobia.
* Cerebral metastases from secondary (non-primary) tumors.
* Absence of baseline BOLD functional MRI and/or baseline neurocognitive assessment.
* Failure to provide written participant information and informed consent.
* Karnofsky Performance Status (KPS) \<60, unless feasibility of clinical-psychological testing and BOLD fMRI is confirmed by the investigator in consultation with clinical psychology, radiology staff, and the patient.

Where it's running

• Kepler University Hospital
  Linz, Upper Austria, Austria Recruiting

Study contacts

• Principal investigator: Michael Sonnberger, MD — Head of Institute of Neuroradiology, Kepler University Hospital Linz, Johannes Kepler University
• Study coordinator: Raimund Kleiser, PD Dr.
• Email: raimund.kleiser@kepleruniklinikum.at
• Phone: +43 5 7680 87 - 26701

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.