Brachytherapy treatment for cervical cancer using interstitial needles

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the feasibility and safety of administering three fractions of high dose rate (HDR) brachytherapy with interstitial needles for patients with cervical cancer in an outpatient setting. It is a single-arm phase II prospective study that will recruit approximately 56 patients over three years at the National University Hospital. The primary objective is to assess clinical outcomes such as local control rates and overall survival, while secondary objectives focus on long-term toxicities associated with the treatment. Patients will undergo thorough pre-treatment assessments and receive tailored brachytherapy based on MRI evaluations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. 21 years old and above
2. Histologically proven squamous cell carcinoma, adenocarcinoma, adenosquamous or poorly differentiated cervical cancer
3. Clinically or radiologically stage IB - IVA cervical cancer based on TNM 8th Edition
4. ECOG performance status 0, 1, or 2
5. To complete external beam radiotherapy and brachytherapy in NUH
6. Written, voluntary informed consent
7. Patients must be accessible for follow up and management in NUH

Exclusion Criteria:

1. Post operative cervical cancer cases
2. Pregnant or breastfeeding women

Where it's running

• National University Hospital
  Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Vicky Koh, MD — National University Hospital, Singapore
• Study coordinator: Fatin Aliyah, BSc
• Email: fatin_hussin@nuhs.edu.sg
• Phone: +6581005851

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.