Botox injections into the neck's sternocleidomastoid (SCM) muscles
Official title: The Effect of Injection of prabotulinumtoxinA-xvfs (Jeuveau) Into the Bilateral Sternocleidomastoid Muscles on Neck Circumference and Aesthetics
Run by Boston Medical Center · NCT06903975 · Data updated 2026-11-12
This will try Botox (prabotulinumtoxinA-xvfs) injected into the sternocleidomastoid muscles to see if it temporarily slims the neck and creates a more feminine, youthful neck contour for adults seeking that change.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Boston Medical Center Academic / other |
| Locations | 1 site (Newton, Massachusetts) |
| Status | Recruiting |
| Started | May 14, 2025 |
| Main results expected | March 2027 |
| Study ends | March 2027 |
| Registry record updated | August 31, 2026 |
| Trial ID | NCT06903975 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults seeking a more feminine neck appearance who are not pregnant or breastfeeding, have BMI ≤30, are not on anticoagulants, and have not had SCM neuromodulator injections within the past year.
✕Probably not a fit
People with BMI over 30, current anticoagulant use, prior allergy to botulinum toxin, pregnancy or breastfeeding, or those expecting significant weight change are unlikely to receive benefit from this procedure.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants receive injections of prabotulinumtoxinA-xvfs into the sternocleidomastoid (SCM) muscles and are followed to measure neck circumference and aesthetic outcomes. Neck circumference is measured at four weeks post-injection and participants complete neck perception and self-confidence surveys to report subjective changes. Safety is tracked by collecting adverse events throughout the study period. The protocol excludes people with recent SCM neuromodulator injections, BMI over 30, anticoagulant use, pregnancy or breastfeeding, allergy to botulinum toxin, or anticipated major weight change.
Why it matters
Potential benefit: If successful, the injections could temporarily reduce neck circumference and improve neck contour and self-confidence.
How similar studies have gone: Injection of botulinum toxin into the SCM has established use for neck spasms, but using SCM injections specifically for cosmetic neck slimming is novel with limited prior evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age eligible individual seeking a more feminine neck appearance Exclusion Criteria: * Prior neuromodulator injections in the sternocleidomastoid muscles (SCM) within the past year * Current anticoagulant use * Body mass index (BMI) \>30 * Anticipation of significant weight gain or loss during the study period (e.g. patients taking or planning to take within the study period a semaglutide medication.) * Prior allergy to botulinum toxin A * Currently pregnant or breastfeeding
Where it's running
-
The Spiegel Center
Newton, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Jeffrey Spiegel, MD — Boston Medical Center and The Spiegel Center
- Study coordinator: Jeffrey Spiegel, MD
- Email: Jeffrey.Spiegel@bmc.org
- Phone: 617 566-3223
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.