Botox injections alone vs with fissurectomy and anoplasty for chronic anal fissure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective study compares two treatments for chronic anal fissure: Botox injections alone versus Botox injections plus fissurectomy and anoplasty. Adults 18–65 with fissures persisting more than 6 weeks and failure of conservative therapy are eligible. The trial will measure healing rate, pain relief, time to healing, recurrence, continence, and patient satisfaction, with 108 participants divided into the two groups and followed post-treatment. Outcomes will help determine if adding a surgical component to Botox provides better results without unacceptable risk. The study is conducted at Islamabad Medical and Dental College in Islamabad.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adults aged 18 to 65 years, regardless of sex Diagnosis of chronic anal fissure persisting for more than 6 weeks Failure of at least 6 weeks of standardized conservative treatment Fit for anesthesia and surgical intervention Willing and able to provide written informed consent

Exclusion Criteria:

Acute anal fissure Inflammatory bowel disease Anal malignancy Previous anal surgery Pregnancy Pre-existing fecal incontinence Immunocompromised patients

Where it's running

• Islamabad Medical and Dental College
  Islamabad, Federal, Pakistan Recruiting

Study contacts

• Study coordinator: Prof. Dr. Rizwan Aziz
• Email: aziz.rizwan@imdcollege.edu.pk
• Phone: +923008444229

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Three LIS techniques for chronic anal fissure healing

  This trial tests three different ways of performing lateral internal sphincterotomy to see which best heals chronic anal fissures with the least risk of incontinence.

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• Combined surgical approach for chronic anal fissure

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• Treatment for chronic anal fissures using E-CEL UVEC cells

  This study is testing if injections of special cells can help people with chronic anal fissures who haven't found relief from regular treatments.

  Recruiting Phase 1 Weill Medical College of Cornell University · New York, New York · NCT06456073

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.