Bone mineral changes after living-donor liver transplant
Official title: Assessment of Changes in Bone Mineral Metabolism After Liver Transplantation by Bone Mineral Densitometry
Run by Institute of Liver and Biliary Sciences, India · NCT07480057 · Data updated 2026-11-12
Bone density scans will be used to see how bone mineral density changes in adults with chronic liver disease who receive a living-donor liver transplant.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Institute of Liver and Biliary Sciences, India Academic / other |
| Locations | 1 site (New Delhi, National Capital Territory of Delhi) |
| Status | Recruiting |
| Started | March 18, 2026 |
| Main results expected | October 30, 2026 |
| Study ends | October 30, 2026 |
| Registry record updated | March 19, 2026 |
| Trial ID | NCT07480057 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 with cirrhosis who are undergoing a living-donor liver transplant at the study center and who provide consent are ideal candidates.
✕Probably not a fit
Patients receiving transplants for acute liver failure, pediatric recipients, deceased-donor recipients, or those who decline consent would not be eligible and would not benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with cirrhosis undergoing living-donor liver transplantation at a single center will have bone mineral density measured by densitometry before and at scheduled intervals after transplant to track changes. The observational protocol collects clinical data and known bone-risk factors such as sex, diabetes, vitamin D status, and pre-existing bone abnormalities without changing standard care. The focus is on early post-transplant bone loss, which prior reports indicate is often greatest in the first year and can increase vertebral fracture risk. No investigational treatments are provided; findings are intended to inform monitoring and prevention strategies.
Why it matters
Potential benefit: If successful, this could help doctors time bone density monitoring and preventive care to reduce osteoporosis and fracture risk after liver transplant.
How similar studies have gone: Multiple prior observational studies have documented early post-transplant bone loss and increased fracture risk, so serial densitometry is a well-established approach rather than novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- All adult patients \>18 yrs with Cirrhosis of Liver undergoing Live Donor Liver Transplant Exclusion Criteria: 1. Patients not giving consent. 2. LT for ALF 3. Pediatric LT recipients 4. DDLT recipients
Where it's running
-
Institute of Liver and Biliary Sciences
New Delhi, National Capital Territory of Delhi, India Recruiting
Study contacts
- Study coordinator: Rahul shivhare, MS
- Email: rahulshivhare93@gmail.com
- Phone: 01146300000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.