Bone loss in the leg treated with Masquelet technique or magnetic bone transport
Official title: Evaluation of the Management of Bone Loss in Orthopaedic Surgery Using the Masquelet Technique or Transport Nails
Run by University Hospital, Bordeaux · NCT07389681 · Data updated 2026-11-12
This study tests whether the Masquelet technique or an electromagnetic transport nail can best rebuild bone in adults with large leg bone defects.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | University Hospital, Bordeaux Academic / other |
| Locations | 1 site (Bordeaux) |
| Status | Recruiting |
| Started | April 27, 2026 |
| Main results expected | March 2029 |
| Study ends | March 2034 |
| Registry record updated | June 5, 2026 |
| Trial ID | NCT07389681 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with a lower-limb segmental bone defect where either Masquelet or electromagnetic transport nail reconstruction is planned.
✕Probably not a fit
Patients whose bone defects heal similarly with both methods or who do not experience improvement may see limited benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center prospective observational study comparing two reconstruction methods for lower-limb bone loss. It aims to compare consolidation times between the Masquelet technique and electromagnetic transport nails, the latter being a novel approach. Secondary outcomes include demographics, functional status, quality of life, hospital stay, and adverse events. Data are collected through patient questionnaires and routine records. The study focuses on metaphyseal-diaphyseal bone loss and is conducted at CHU de Bordeaux under the lead sponsor, University Hospital, Bordeaux.
Why it matters
Potential benefit: If successful, the study could help identify which method enables faster or more reliable bone healing and better patient-reported outcomes.
How similar studies have gone: Previous literature suggests both techniques have been used with varying results; this study represents one of the first prospective comparisons of the two approaches.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient ≥ 18 years * Minor patient, able to consent to data collection, with the consent of the owner(s) * Patient consulting for a medical reason involving a loss of bone substance in the lower limb in an investigating centre linked to one of these aetiologies for which a reconstruction procedure using a transport nail or Masquelet technique is envisaged: * Tumour pathologies requiring * Septic or aseptic pseudarthrosis * Traumatic pathology * Infectious pathologies Exclusion Criteria: * Patients under guardianship or curatorship, * Individuals deprived of their liberty by judicial or administrative decision, * Individuals receiving involuntary psychiatric care requiring the consent of their legal representative, * Individuals unable to express their consent, * Individuals under legal protection, * Patients with an indication for bone reconstruction using a technique other than the Masquelet technique and nail transport, * Patients not covered by a social security scheme, * Patients ineligible for bone reconstruction due to their comorbidities
Where it's running
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CHU de Bordeaux
Bordeaux, France Recruiting
Study contacts
- Principal investigator: Benjamin BOUYER, PROF — University Hospital, Bordeaux
- Study coordinator: Benjamin BOUYER, PROF
- Email: b.bouyer@chu-bordeaux.fr
- Phone: +335 56 79 87 18
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.