Bone healing with platelet-rich fibrin after jaw cyst removal
Official title: Clinical Efficacy of Platelet-Rich Fibrin in Osseous Regeneration After Cystic Enucleation
Run by Sana'a University · NCT07424716 · Data updated 2026-11-12
This trial will test whether using your own platelet-rich fibrin (PRF) during jaw cyst removal helps bone heal faster and more completely in adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Sana'a University Academic / other |
| Locations | 1 site (Sanaa, Sanaa Governorate) |
| Status | Recruiting |
| Started | May 19, 2025 |
| Main results expected | April 19, 2026 |
| Study ends | October 19, 2026 |
| Registry record updated | February 20, 2026 |
| Trial ID | NCT07424716 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older who are systemically healthy (ASA I–II) and scheduled for surgical enucleation of an odontogenic jaw cyst without active infection are ideal candidates.
✕Probably not a fit
Patients with conditions that impair bone healing (for example uncontrolled diabetes or osteoporosis), those on bisphosphonates or long-term corticosteroids, heavy smokers, pregnant or lactating women, or those with active surgical-site infection are unlikely to benefit or may be excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized controlled trial comparing autologous platelet-rich fibrin (PRF) placed into the bone defect after cyst enucleation versus conventional surgical management without PRF. Adults undergoing odontogenic cyst removal will be randomly assigned to the PRF group or the control group. Clinical and radiographic assessments will be performed over scheduled follow-up visits to measure bone regeneration, healing rate, and postoperative outcomes. The trial has ethical approval from the Ethical Committee of the Faculty of Medicine and Health Sciences, Sana'a University, and is conducted at Sana'a University in Yemen.
Why it matters
Potential benefit: If successful, PRF could provide a minimally invasive, lower-cost way to improve bone healing after jaw cyst removal and reduce the need for grafting or additional surgery.
How similar studies have gone: Smaller trials and case series in oral and maxillofacial surgery have shown promising improvements in bone healing with PRF, but high-quality randomized data are still limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients diagnosed with odontogenic cysts requiring surgical enucleation. * Presence of a postoperative osseous defect in the jaws after cyst enucleation. * Age ≥ 18 years. * Systemically healthy patients (ASA I or II). * Patients willing to participate and sign informed consent. Exclusion Criteria: * Patients with systemic diseases affecting bone healing (e.g., uncontrolled diabetes, osteoporosis). * Patients receiving bisphosphonates or long-term corticosteroid therapy. * Smokers (\>10 cigarettes/day). * Pregnant or lactating women. * Patients with acute infection at the surgical site. * Patients unwilling to participate or unable to attend follow-up visits.
Where it's running
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Faculty of Medicine and Health Sciences - Sana'a University
Sanaa, Sanaa Governorate, Yemen Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.