Bone density after different estrogen treatments in young women with amenorrhea
Official title: Retrospective Observational Evaluation of the Bone Mineral Density Outcome of Different Oestrogen Therapy Regimens in Young Women With Amenorrhea
Run by IRCCS Azienda Ospedaliero-Universitaria di Bologna · NCT07015476 · Data updated 2026-11-12
This project tests whether different estrogen treatment plans help improve bone density in young women (about 15–39) who have gone more than six months without periods.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 15 Years to 39 Years |
| Sex | Women only |
| Enrollment | 180 (estimated) |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna Academic / other |
| Locations | 1 site (Bologna) |
| Status | Recruiting |
| Started | November 9, 2020 |
| Main results expected | October 2025 |
| Study ends | November 2026 |
| Registry record updated | June 11, 2025 |
| Trial ID | NCT07015476 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged about 15–39 who experienced amenorrhea for more than six months and who attended the Bologna clinic between 2011 and 2020 with documented baseline and follow-up DXA scans and recorded estrogen therapy.
✕Probably not a fit
Patients without baseline or follow-up DXA data, those who never received estrogen therapy, or those with incomplete medical records are unlikely to contribute useful information and therefore may not benefit from this analysis.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a retrospective, single-center observational analysis of patients seen at the Gynecology and Reproductive Medicine unit in Bologna between 2011 and 2020 with amenorrhea lasting over six months. Researchers compare baseline and follow-up DXA scans (lumbar spine, femur, whole body) taken at least one year apart to see how different estrogen regimens affect bone mineral density, T-scores, and Z-scores. The study also extracts clinical history, physical exam findings, pelvic ultrasound results, blood tests, and specialist reports from medical records to explore other systemic and metabolic effects of the therapies. No interventions are applied because the analysis uses existing patient records.
Why it matters
Potential benefit: If successful, the findings could identify estrogen regimens that better preserve or increase bone mass in young women with prolonged hypoestrogenism and help guide treatment choices to reduce long-term fracture risk.
How similar studies have gone: Previous research shows estrogen therapy can improve bone density in hypoestrogenic women, but direct comparisons of different estrogen regimens in this young population are limited, so this work builds on established effects while adding comparative detail.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * Patients who have presented themselves to the O.U. of Gynecology and Human Reproduction Pathophysiology in the period from 2011 to 2020 with amenorrhea over 6 months, and aged between 15 and 39 years at the time of the visit. * Patients who have reached the age of 18 at the time of surgery. * Patients for whom informed consent has been obtained. Exclusion criteria: No exclusion criteria are provided.
Where it's running
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IRCCS Azienda Ospedaliero -Univeristaria di Bologna
Bologna, Italy Recruiting
Study contacts
- Principal investigator: Maria C Meriggiola, MD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Study coordinator: Maria C Meriggiola, MD
- Email: cristina.meriggiola@unibo.it
- Phone: 0512144394
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.