Body composition changes after metabolic surgery in adults with severe obesity
Official title: Outcome of Body Composition Assessment in Patients With Severe Obesity Undergoing Metabolic Surgery
Run by Pennington Biomedical Research Center · NCT07530718 · Data updated 2026-11-12
This study tests advanced body composition tools to see if they give better, more clinically useful data on outcomes after metabolic surgery for adults with severe obesity.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Pennington Biomedical Research Center Academic / other |
| Locations | 2 sites (Baton Rouge, Louisiana and 1 other locations) |
| Status | Recruiting |
| Started | April 14, 2026 |
| Main results expected | February 1, 2027 |
| Study ends | March 31, 2027 |
| Registry record updated | June 17, 2026 |
| Trial ID | NCT07530718 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with BMI ≥40 kg/m2, weigh <440 pounds, scheduled for primary metabolic surgery (SG or RYGB), and able to comply with study procedures.
✕Probably not a fit
Patients who do not undergo metabolic surgery or have contraindications to the imaging methods may not experience these potential assessments.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will compare body composition measurement tools in adults with BMI ≥40 kg/m2 undergoing Sleeve Gastrectomy or Roux-en-Y Gastric Bypass. It aims to track changes in fat and muscle, and muscle strength, to determine which methods most accurately reflect physical changes after surgery. The project will also compare body composition changes between SG and RYGB patients and generate pilot data to guide future assessments. Eligible participants are adults with severe obesity scheduled for primary metabolic surgery at Pennington Biomedical Research Center, with keys on safety and compliance. The study builds on prior work suggesting more nuanced measures may outperform traditional metrics like BMI.
Why it matters
Potential benefit: If successful, the study could identify better ways to monitor body fat loss and muscle preservation after metabolic surgery, informing clinical care and follow-up.
How similar studies have gone: Prior research has used a 3-compartment model and similar tools in high-BMI patients, but broader validation and direct comparison across SG and RYGB remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Being either male or female * Being an adult greater or equal to 18 years of age * BMI ≥40 kg/m2 * Weigh less than 440 pounds * Being willing to comply with the study procedures * Being scheduled for primary metabolic surgery (either Sleeve Gastrectomy or Roux-en-Y Gastric bypass) Exclusion Criteria: * Previous bariatric surgery or other complex abdominal surgery * Poorly controlled medical or psychiatric disorders * For women in child-bearing ages, being pregnant or attempting to become pregnant or currently breastfeeding * Having metal-containing objects in their body that may cause artifact on MRI * Having medical implants such as a pacemaker or metal joint replacements * Having a body weight greater than 440 pounds * Comorbid conditions that may affect body composition measurements, such as advanced liver disease or severe cardiovascular disease. * Cannot understand risks, benefits, and compliance required to participate.
Where it's running
-
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States Recruiting -
Pennington Biomedical Resarch Center
Baton Rouge, Louisiana, United States Not yet recruiting
Study contacts
- Study coordinator: Zubaidah Nor Hanipah, MD
- Email: zubaidah.norhanipah@pbrc.edu
- Phone: 225-763-2831
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.